Schizophrenia risk factors in exceptional achievers: a re-analysis of a 60-year-old database
Schizophrenia risk factors in exceptional achievers: a re-analysis of a 60-year-old database
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杰出成就者的精神分裂症风险因素：对 60 年前数据库的重新分析
DOI：
10.1038/s41598-018-37484-9
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发表时间：
2019
影响因子：
4.6
通讯作者：
F. Schürhoff
中科院分区：
文献类型：
--
作者：
A. Szöke;B. Pignon;F. Schürhoff
目前的医学研究集中在疾病及其相关的危险因素上。因此，这些因素被认为有有害的影响。另一种假设是，其中一些风险因素也会增加出现相反、积极结果的机会。为了验证这一假设，我们认为卓越的社会成就和精神分裂症是相反的结果。60年前，法国的研究人员收集了与特殊社会成就相关的社会人口因素的数据。由于原始数据库中女性受试者的数量非常有限，我们将分析限制在男性。我们测试了在已知与精神分裂症风险增加相关的因素（即移民、城市化、出生季节性、出生顺序和父亲年龄）存在的情况下取得显著成就的几率。在测试的五个因素中，有三个因素显著增加了获得特殊社会成就的几率（城市出生、长子和父亲年龄超过35岁）。我们的研究结果表明，目前被认为是精神分裂症危险因素的一些因素可以使因素多样化。扩大研究的重点，包括与疾病相关因素的所有潜在影响，可能对我们理解因果机制和设计公共卫生干预措施产生重要影响。
Current medical research has focused on diseases and their associated risk factors. As such, these factors are assumed to have a deleterious effect. An alternative hypothesis is that some of these risk factors would also increase the chance for an opposite, positive outcome. To test this hypothesis, we considered exceptional social achievement and schizophrenia as opposite outcomes. Sixty years ago, researchers in France collected data on socio-demographic factors associated with exceptional social achievement. As the number of female subjects in the original database was very limited, we restricted our analyses to men. We tested the odds of achieving prominence in the presence of factors known to be associated with an increased risk of schizophrenia, namely migration, urbanicity, seasonality of birth, birth order, and paternal age. Three of the five factors tested significantly increased the odds for exceptional social achievement (urban birth, being the first-born and father’s age over 35). Our findings suggest that some of the factors that are currently considered as risk factors for schizophrenia could diversifying factors. Widening the focus of research to include all potential effects of factors associated with disease could have important consequences on our understanding of causal mechanisms and for designing public health interventions.
影响因子：
--
作者：
E. Susser;R. Neugebauer;H. Hoek;A. Brown;S. Lin;D. Labovitz;J. Gorman
通讯作者：
E. Susser;R. Neugebauer;H. Hoek;A. Brown;S. Lin;D. Labovitz;J. Gorman
影响因子：
5
作者：
Ekamper, Peter;van Poppel, Frans;Lumey, L. H.
通讯作者：
Lumey, L. H.