Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians.
Exposure to maternal gestational diabetes is associated with higher cardiovascular responses to stress in adolescent indians.
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DOI：
10.1210/jc.2014-3239
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发表时间：
2015-03
期刊：
影响因子：
--
通讯作者：
Fall CH
中科院分区：
文献类型：
--
作者：
Krishnaveni GV;Veena SR;Jones A;Srinivasan K;Osmond C;Karat SC;Kurpad AV;Fall CH
内分泌和自主神经系统对压力反应的改变可能会将子宫内生长受损与后来的心血管疾病联系起来。为了检验妊娠糖尿病母亲 (OGDM) 的后代在特里尔儿童社会压力测试 (TSST-C) 期间具有较高皮质醇和心脏交感神经反应的假设。来自印度出生队列的青少年（n = 213；平均年龄为 13.5 岁），包括 26 名 OGDM、22 名糖尿病父亲的后代 (ODF) 和 165 名非糖尿病父母的后代（对照），在两名陌生的“评估者”(TSST-C) 面前完成了各 5 分钟的公开演讲和心算任务。在基线和 TSST-C 之后定期测量唾液皮质醇浓度。使用指套在基线、TSST-C 期间以及测试后 10 分钟内连续测量心率、血压 (BP)、每搏输出量、心输出量和总外周阻力；逐次心跳值是这些时期的平均值。应激期间皮质醇和心脏交感神经参数较基线有所增加 (P < .001)。与应激期间的对照组相比，OGDM 的收缩压（平均差 5.6 mm Hg）、心输出量（0.5 L/min）和每搏输出量（4.0 mL）增加较多，总外周阻力上升较低（125 dyn·s/cm5）。 ODF 的收缩压反应比对照组更大（差异为 4.1 mm Hg）；其他心脏交感神经参数没有差异。所有三组的皮质醇反应相似。怀孕期间母亲患有糖尿病与后代较高的心脏交感神经应激反应有关，这可能导致其较高的心血管疾病风险。进一步的研究可能会证实压力反应编程是 OGDM 心血管风险的预测因子。
Altered endocrinal and autonomic nervous system responses to stress may link impaired intra-uterine growth with later cardiovascular disease. To test the hypothesis that offspring of gestational diabetic mothers (OGDM) have high cortisol and cardiosympathetic responses during the Trier Social Stress Test for Children (TSST-C). Adolescents from a birth cohort in India (n = 213; mean age, 13.5 y), including 26 OGDM, 22 offspring of diabetic fathers (ODF), and 165 offspring of nondiabetic parents (controls) completed 5 minutes each of public speaking and mental arithmetic tasks in front of two unfamiliar “evaluators” (TSST-C). Salivary cortisol concentrations were measured at baseline and at regular intervals after the TSST-C. Heart rate, blood pressure (BP), stroke volume, cardiac output, and total peripheral resistance were measured continuously at baseline, during the TSST-C, and for 10 minutes after the test using a finger cuff; the beat-to-beat values were averaged for these periods. Cortisol and cardiosympathetic parameters increased from baseline during stress (P < .001). OGDM had greater systolic BP (mean difference, 5.6 mm Hg), cardiac output (0.5 L/min), and stroke volume (4.0 mL) increases and a lower total peripheral resistance rise (125 dyn · s/cm5) than controls during stress. ODF had greater systolic BP responses than controls (difference, 4.1 mm Hg); there was no difference in other cardiosympathetic parameters. Cortisol responses were similar in all three groups. Maternal diabetes during pregnancy is associated with higher cardiosympathetic stress responses in the offspring, which may contribute to their higher cardiovascular disease risk. Further research may confirm stress-response programming as a predictor of cardiovascular risk in OGDM.
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影响因子：
5.2
作者：
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通讯作者：
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DOI：
10.1016/j.ecl.2012.10.002
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作者：
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影响因子：
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作者：
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通讯作者：
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