CD10 is expressed in a subset of chromophobe renal cell carcinomas
CD10 is expressed in a subset of chromophobe renal cell carcinomas
复制标题
CD10 在一部分嫌色肾细胞癌中表达
作者：
G. Martignoni;M. Pea;M. Brunelli;M. Chilosi;A. Zamó;Manuela Bertaso;P. Cossu;J. Eble;G. Mikuz;G. Puppa;C. Badoual;V. Ficarra;G. Novella;F. Bonetti
由于CD 10在透明细胞和乳头状肾细胞癌中表达，而在嫌色细胞肾细胞癌中不表达，因此CD 10被认为是诊断肾癌的有用标志物。另一方面，嫌色细胞肾细胞癌表达小清蛋白，而透明细胞和乳头状肾细胞癌中不表达。为了进一步阐明这些标志物的相关性，我们研究了42例嫌色细胞肾细胞癌（其中7例具有侵袭性特征，包括肾包膜外浸润、肾静脉浸润、转移或肉瘤样转化）、75例透明细胞肾细胞癌（8例转移）和51例乳头状肾细胞癌（2例转移）中CD 10和小清蛋白的表达。100%的透明细胞肾细胞癌、63%的乳头状肾细胞癌和所有两种类型的转移性病例中发现了CD 10。与以前的研究不同，我们发现CD 10表达在30 - 90%的肿瘤细胞中，42例嫌色细胞肾细胞癌中有11例（26%）。CD 10阳性病例包括7例中的5例（71%）具有侵袭性特征的嫌色细胞肾细胞癌。统计学分析显示CD 10阳性肿瘤与临床病理侵袭性（P=0.003）和核分裂像（P=0.04）显著相关。小清蛋白在所有原发性和转移性嫌色细胞肾细胞癌中均强表达。免疫印迹分析用于确认CD 10和小清蛋白在嫌色细胞肾细胞癌中的表达。
CD10 has been considered a useful marker in the diagnosis of renal carcinomas, because of its expression in clear cell and papillary renal cell carcinomas and its absence in chromophobe renal cell carcinomas. On the other hand, chromophobe renal cell carcinoma expresses parvalbumin, which is absent in clear cell and papillary renal cell carcinomas. To further address the relevance of these markers, we studied the expression of CD10 and parvalbumin in 42 samples of chromophobe renal cell carcinoma (seven of which had aggressive features, including invasion beyond the renal capsule, renal vein invasion, metastases, or sarcomatoid transformation), 75 clear cell renal cell carcinomas (eight metastatic) and 51 papillary renal cell carcinomas (two metastatic). CD10 was found in 100% of clear cell renal cell carcinomas, 63% of papillary renal cell carcinomas and in all metastatic cases of both types. At variance with previous studies, we found CD10 expression in from 30 to 90% of the neoplastic cells, in 11 of 42 (26%) chromophobe renal cell carcinomas. The CD10-positive cases included five of the seven (71%) chromophobe renal cell carcinoma with aggressive features. Statistical analysis showed significant association of CD10-positive tumors with clinicopathologic aggressiveness (P=0.003) and mitotic figures (P=0.04). Parvalbumin was strongly expressed in all primary and metastatic chromophobe renal cell carcinomas. Western blot analysis was utilized to confirm the expression of both CD10 and parvalbumin in chromophobe renal cell carcinomas.
影响因子：
6
作者：
Higgins, JPT;Shinghal, R;Brooks, JD
通讯作者：
Brooks, JD