Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area.
Behavior-Dependent Activity and Synaptic Organization of Septo-hippocampal GABAergic Neurons Selectively Targeting the Hippocampal CA3 Area.
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DOI：
10.1016/j.neuron.2017.10.033
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发表时间：
2017-12-20
期刊：
影响因子：
16.2
通讯作者：
Somogyi P
中科院分区：
文献类型：
--
作者：
Joshi A;Salib M;Viney TJ;Dupret D;Somogyi P
节律性内侧隔（MS）GABA能输入协调皮质θ振荡。然而，不同的隔神经元对皮层细胞和区域的神经支配的规则是未知的。我们报告了一个特殊的隔GABA能神经元群体，Teevra细胞，选择性地支配海马CA 3区绕过CA 1，CA 2和齿状回。小清蛋白免疫阳性的Teevra细胞表现出最高的MS神经元之间的节律性和火灾与短的突发持续时间（中位数，38毫秒）优先在槽的CA 1 θ和缓慢的不规则振荡，符合最高的海马兴奋性。Teevra细胞突触靶向限制性隔颞CA 3节段中的GABA能轴突-轴突和一些CCK中间神经元。其发射的节律性从间隔到单个轴突的时间终止降低。我们假设，Teevra神经元协调振荡活动跨隔-颞轴，定相特定的CA 3中间神经元的发射，从而有助于通过去抑制在θ谷锥体细胞组件的选择。节律性放电的内侧隔神经元聚集成不同的亚群最有节律的GABA能Teevra细胞放电与海马兴奋一致Teevra细胞优先支配CA 3轴-轴和CCK GABA能中间神经元Teevra轴突限于CA 3隔-颞段反映节律性的程度使用一致的神经元特征，Joshi et al.定义了最有节奏的内侧隔GABA能细胞类型，Teevra细胞，其优先支配海马CA 3中的轴-轴GABA能中间神经元。这种选择性终止通过去抑制协调海马兴奋性和θ振荡。
Rhythmic medial septal (MS) GABAergic input coordinates cortical theta oscillations. However, the rules of innervation of cortical cells and regions by diverse septal neurons are unknown. We report a specialized population of septal GABAergic neurons, the Teevra cells, selectively innervating the hippocampal CA3 area bypassing CA1, CA2, and the dentate gyrus. Parvalbumin-immunopositive Teevra cells show the highest rhythmicity among MS neurons and fire with short burst duration (median, 38 ms) preferentially at the trough of both CA1 theta and slow irregular oscillations, coincident with highest hippocampal excitability. Teevra cells synaptically target GABAergic axo-axonic and some CCK interneurons in restricted septo-temporal CA3 segments. The rhythmicity of their firing decreases from septal to temporal termination of individual axons. We hypothesize that Teevra neurons coordinate oscillatory activity across the septo-temporal axis, phasing the firing of specific CA3 interneurons, thereby contributing to the selection of pyramidal cell assemblies at the theta trough via disinhibition. Rhythmically firing medial septal neurons cluster into distinct subpopulations The most rhythmic GABAergic Teevra cells fire coincident with hippocampal excitation Teevra cells preferentially innervate CA3 axo-axonic and CCK GABAergic interneurons Teevra axons restricted to CA3 septo-temporal segments reflect degree of rhythmicity Using congruent neuronal features, Joshi et al. define the most rhythmic medial septal GABAergic cell type, the Teevra cells, which preferentially innervate axo-axonic GABAergic interneurons in the hippocampal CA3. Such selective termination coordinates hippocampal excitability and theta oscillations via disinhibition.
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