Lipid bilayers: clusters, domains and phases.

Lipid bilayers: clusters, domains and phases.
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DOI:
10.1042/bse0570033
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发表时间:
2015
影响因子:
6.4
通讯作者:
Feigenson GW
Feigenson GW
中科院分区:
生物学2区
文献类型:
--
作者:
Ackerman DG;Feigenson GW

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在本章中,我们讨论质膜脂质的复杂混合行为。为此,我们首先介绍常用于模拟其复杂性的质膜和膜混合物。然后,我们讨论双层中脂质相行为的性质,以及这些相与单相混合物中发现的非随机混合的其他表现(例如簇、胶束和微乳液)之间的区别。最后,我们证明了吉布斯相图在研究日益复杂的模型膜系统中的适用性,重点是相共存、形态及其对细胞质膜的影响。
In this chapter we discuss the complex mixing behavior of plasma membrane lipids. To do so, we first introduce the plasma membrane and membrane mixtures often used to model its complexity. We then discuss the nature of lipid phase behavior in bilayers and the distinction between these phases and other manifestations of nonrandom mixing found in one-phase mixtures, such as clusters, micelles, and microemulsions. Finally, we demonstrate the applicability of Gibbs phase diagrams to the study of increasingly complex model membrane systems, with a focus on phase coexistence, morphology and their implications for the cell plasma membrane.
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