Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.
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DOI：
10.1016/j.tips.2010.02.003
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发表时间：
2010-05
影响因子：
13.8
通讯作者：
Guarente L
中科院分区：
文献类型：
--
作者：
Imai S;Guarente L
在过去的十年中，自从发现SIR2（沉默信息调节因子2）家族的NAD依赖性脱乙酰酶活性（现在称为“sirtuins”）以来，蛋白质脱乙酰化和能量代谢之间的许多令人兴奋的联系已经被揭示。sirtuins的重要性已被牢固地建立在许多基本的生物反应的各种营养和环境刺激的调节。Sirtuins也已成为模式生物衰老和长寿的关键调节剂。它们对NAD的绝对需求使哺乳动物NAD生物合成的研究重新燃起了热情。此外，针对年龄相关疾病的抗衰老靶向药物和营养干预措施现已出现。本文综述了近年来sirtuin的研究进展，特别是哺乳动物sirtuin的生物学研究进展，并对sirtuin与代谢和2型糖尿病等年龄相关疾病的关系进行了重新评价，为今后10年sirtuin的研究奠定了基础。
In the past decade since the discovery of NAD-dependent deacetylase activity of the SIR2 (silent information regulator 2) family, now called “sirtuins,” many exciting connections between protein deacetylation and energy metabolism have been revealed. The importance of sirtuins have been firmly established in the regulation of many fundamental biological responses to a variety of nutritional and environmental stimuli. Sirtuins have also emerged as critical regulators for aging and longevity in model organisms. Their absolute requirement of NAD has revived an enthusiasm in the study of mammalian NAD biosynthesis. Furthermore, sirtuin-targeted pharmaceutical and nutriceutical interventions against age-associated diseases are now on the horizon. This review will summarize the recent progress in sirtuin research, particularly in the field of mammalian sirtuin biology, and reevaluate the connection between sirtuins, metabolism, and age-associated diseases, such as type 2 diabetes, to set a milepost for the next 10 years of sirtuin research.
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