Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases.
Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases.
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DOI：
10.1155/2015/673090
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发表时间：
2015
影响因子：
4.6
通讯作者：
Santiago AR
中科院分区：
文献类型：
--
作者：
Madeira MH;Boia R;Santos PF;Ambrósio AF;Santiago AR
视网膜退行性疾病是世界范围内视力丧失和失明的主要原因，其特征是慢性和进行性神经元丧失。视网膜退行性疾病和脑神经退行性疾病的一个共同特征是慢性神经炎症。越来越多的证据表明，视网膜小胶质细胞在视网膜退行性疾病的过程中被激活，在神经退行性过程的开始和传播中起着关键作用。更好地了解视网膜小胶质细胞引发和介导的事件将有助于澄清疾病的病因，并可能为潜在的治疗干预开辟新的途径。本文综述了小胶质细胞介导的神经炎症在青光眼、年龄相关性黄斑变性和糖尿病视网膜病变等主要视网膜退行性疾病中的作用。
Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.
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影响因子：
16.2
作者：
通讯作者：
--
影响因子：
2.7
作者：
Brucklacher, Robert M.;Patel, Kruti M.;Freeman, Willard M.
通讯作者：
Freeman, Willard M.
DOI：
10.2147/opth.s19453
发表时间：
2011
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Balaiya S;Edwards J;Tillis T;Khetpal V;Chalam KV
通讯作者：
Chalam KV
影响因子：
3.8
作者：
Aveleira, Celia;Castilho, Aurea;Ambrosio, Antonio Francisco
通讯作者：
Ambrosio, Antonio Francisco
影响因子：
2.5
作者：
Bosco, Alejandra;Steele, Michael R.;Vetter, Monica L.
通讯作者：
Vetter, Monica L.