PartsGenie: an integrated tool for optimising and sharing synthetic biology parts
PartsGenie: an integrated tool for optimising and sharing synthetic biology parts
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PartsGenie：优化和共享合成生物学零件的集成工具
DOI：
10.1101/189357
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
D. Kell
中科院分区：
文献类型：
--
作者：
Neil Swainston;M. Dunstan;A. Jervis;C. Robinson;Pablo Carbonell;Alan R. Williams;J. Faulon;N. Scrutton;D. Kell
合成生物学的典型特征是从可重复使用的合成DNA部分的组装中开发新的遗传构建体，所述合成DNA部分包含一个或多个特征，例如启动子、核糖体结合位点、编码序列和终止子。虽然存在这些部件的存储库以促进其重用，但仍然需要从头开始设计新颖的部件。PartsGenie可在http://parts.synbiochem.co.uk上免费获得，它被引入以促进此类合成生物学部件的计算设计。PartsGenie旨在弥合新型部件设计的优化工具之间的差距，这些部件在社区开发的数据标准（如合成生物学开放语言（SBOL））中的表示，以及它们在期刊推荐的数据存储库中的共享。PartsGenie由拖放式Web界面、多种DNA优化算法和常用数据存储库JBEI ICE的界面组成，通过单个集成应用程序促进了可重复使用的合成生物学部件的设计、优化和传播。因此，PartsGenie可以作为一个单独的工具使用，也可以集成到SYNBIOCHEM中心和其他地方正在开发的更大的合成生物学管道中。
Synthetic biology is typified by developing novel genetic constructs from the assembly of reusable synthetic DNA parts, which contain one or more features such as promoters, ribosome binding sites, coding sequences and terminators. While repositories of such parts exist to promote their reuse, there is still a need to design novel parts from scratch. PartsGenie, freely available at http://parts.synbiochem.co.uk, is introduced to facilitate the computational design of such synthetic biology parts. PartsGenie has been designed to bridge the gap between optimisation tools for the design of novel parts, the representation of such parts in community-developed data standards such as Synthetic Biology Open Language (SBOL), and their sharing in journal-recommended data repositories. Consisting of a drag-and-drop web interface, a number of DNA optimisation algorithms, and an interface to the well-used data repository JBEI ICE, PartsGenie facilitates the design, optimisation and dissemination of reusable synthetic biology parts through a single, integrated application. PartsGenie can therefore be used as a single, stand-alone tool, or integrated into larger synthetic biology pipelines that are being developed in the SYNBIOCHEM centre and elsewhere.
影响因子：
14.9
作者：
SHARP, PM;LI, WH
通讯作者：
LI, WH