Oxidative stress and its biomarkers in systemic lupus erythematosus.
Oxidative stress and its biomarkers in systemic lupus erythematosus.
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DOI：
10.1186/1423-0127-21-23
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发表时间：
2014-03-17
影响因子：
11
通讯作者：
Paudyal B
中科院分区：
文献类型：
--
作者：
Shah D;Mahajan N;Sah S;Nath SK;Paudyal B
系统性红斑狼疮(SLE)是一种自身免疫性炎症性疾病，其病因尚不清楚。系统性红斑狼疮的氧化应激失控导致细胞蛋白质、脂质和DNA的功能性氧化修饰，氧化修饰的后果在免疫调节和触发自身免疫中起着至关重要的作用。对SLE患者生物样本中氧化修饰蛋白、脂质和DNA的检测有助于阐明氧化应激相关损伤的病理生理机制，预测疾病预后，并在疾病早期选择适当的治疗方法。这些生物标志物在疾病中的应用可能预示着治疗的早期效果。本文就疾病状态下形成的各种活性氧及其与疾病相关的生物标志物作一综述。综述的第一部分介绍了ROS的生物化学和病理生理学以及疾病中的抗氧化系统。综述的第二部分讨论了与SLE患者和动物模型发病机制相关的氧化应激生物标志物的最新进展。最后，本综述还介绍了已报道的抗氧化剂在疾病中的临床试验，这些试验评估了抗氧化剂在正在进行的常规治疗中对疾病的管理效果。
Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease whose etiology remains largely unknown. The uncontrolled oxidative stress in SLE contributes to functional oxidative modifications of cellular protein, lipid and DNA and consequences of oxidative modification play a crucial role in immunomodulation and trigger autoimmunity. Measurements of oxidative modified protein, lipid and DNA in biological samples from SLE patients may assist in the elucidation of the pathophysiological mechanisms of the oxidative stress-related damage, the prediction of disease prognosis and the selection of adequate treatment in the early stage of disease. Application of these biomarkers in disease may indicate the early effectiveness of the therapy. This review is intended to provide an overview of various reactive oxygen species (ROS) formed during the state of disease and their biomarkers linking with disease. The first part of the review presents biochemistry and pathophysiology of ROS and antioxidant system in disease. The second part of the review discusses the recent development of oxidative stress biomarkers that relates pathogenesis in SLE patients and animal model. Finally, this review also describes the reported clinical trials of antioxidant in the disease that have evaluated the efficacy of antioxidant in the management of disease with ongoing conventional therapy.
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影响因子：
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