Age- and gender-related macro- and micro-architecture changes in bone structure and implications for treatment
Age- and gender-related macro- and micro-architecture changes in bone structure and implications for treatment
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与年龄和性别相关的骨结构宏观和微观结构变化及其对治疗的影响
DOI：
10.2217/ijr.11.24
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
M. Brandi
中科院分区：
文献类型：
--
作者：
L. Cavalli;M. Brandi
骨骼是一种动态组织，能够通过建模过程调整其形状和大小以响应机械载荷，并通过重塑不断更新。这些过程受到遗传、荷尔蒙和生活方式因素的影响。骨强度与年龄相关的变化取决于骨密度和骨结构，并且具有性别特异性，这解释了男性和女性特定部位骨质疏松性骨折发生率的差异。尽管雌激素缺乏在女性中更为明显，但它似乎是两性骨质疏松症的主要原因之一。大多数用于治疗骨质疏松症的药物都已在绝经后妇女身上进行过测试；尽管如此，一些药物已被证明对男性也有效。对患者病史的准确检查，可能借助放射学和先进的骨质量成像技术，应指导医生选择最合适的治疗方法。
Bone is a dynamic tissue, which has the ability to adapt its shape and size in response to mechanical loads through the modeling process, and to be constantly renewed by remodeling. These processes are influenced by genetic, hormonal and lifestyle factors. Age-related variation in bone strength, which depends both on bone density and bone structure, are gender-specific, and this explains the difference in the incidence of osteoporotic fractures at specific sites between men and women. Even though estrogen deficiency is more pronounced in women, it appears to be one of the major causes of osteoporosis in both genders. Most of the drugs used to treat osteoporosis have been tested on postmenopausal women; nevertheless, some drugs have been shown to be effective also in men. An accurate examination of the medical history of the patient, possibly with the aid of radiological and advanced techniques to image bone quality should direct the physician in selecting the most appropriate therapy.
影响因子：
4.1
作者：
Carpenter, R. D.;Sigurdsson, S.;Zhao, S.;Lu, Y.;Eiriksdottir, G.;Sigurdsson, G.;Jonsson, B. Y.;Prevrhal, S.;Harris, T. B.;Siggeirsdottir, K.;Guonason, V.;Lang, T. F.
通讯作者：
Lang, T. F.
影响因子：
158.5
作者：
SMITH, EP;BOYD, J;KORACH, KS
通讯作者：
KORACH, KS