Effects of age and sex on the strength and cortical thickness of the femoral neck.
Effects of age and sex on the strength and cortical thickness of the femoral neck.
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DOI：
10.1016/j.bone.2010.12.004
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发表时间：
2011-04-01
期刊：
影响因子：
4.1
通讯作者：
Lang, T. F.
中科院分区：
文献类型：
--
作者：
Carpenter, R. D.;Sigurdsson, S.;Zhao, S.;Lu, Y.;Eiriksdottir, G.;Sigurdsson, G.;Jonsson, B. Y.;Prevrhal, S.;Harris, T. B.;Siggeirsdottir, K.;Guonason, V.;Lang, T. F.
一组 48 名男性（22 名 65-75 岁，26 名 80-90 岁）和 59 名女性（32 名 65-75 岁，27 名 80-90 岁）参加了年龄、基因/环境易感性-雷克雅未克研究，并使用体内体积定量计算机断层扫描 (QCT) 进行成像，以研究年龄和性别对年龄、基因/环境敏感性的影响。股骨颈的结构和强度。计算最小横截面积（minCSA）位置处的股骨颈横截面惯性矩（IAP）、弯曲强度（My）和轴向抗压强度（Fy）。根据延伸穿过 minCSA 股骨颈部分皮质的密度分布，计算下股骨颈的局部皮质厚度。考虑身高、体重和年龄组（年轻或年长）的多变量模型显示，男性的 My 比女性高 46%，Fy 比女性高 23%，而女性的下皮层比男性厚 13%。调整总体积骨矿物质密度后，股骨颈下后部区域的皮质厚度与弯曲和轴向强度显着相关。 minCSA 和 IAP 在年龄较大的性别混合年龄组中均较高，但两个年龄组之间的 Fy 和 My 没有差异。结果表明，与年龄相关的股骨颈扩张主要发生在上下方向，有助于维持股骨颈刚度和强度的稳态。男性股骨颈较高的弯曲强度可能部分解释了为什么老年男性髋部骨折的风险低于老年女性。
A group of 48 men (22 aged 65–75 years, 26 aged 80–90 years) and 59 women (32 aged 65–75 years, 27 aged 80–90 years) were enrolled in the Age, Gene/Environment Susceptibility-Reykjavik study and imaged with in-vivo volumetric Quantitative Computed Tomography (QCT) to investigate the effects of age and sex on femoral neck structure and strength. Femoral neck cross-sectional moment of inertia for bending directions near those of standing and walking (IAP), bending strength (My), and axial compressive strength (Fy) were computed at the location of minimum cross-sectional area (minCSA). Local cortical thickness was computed in the inferior femoral neck based on density profiles extending through the cortex of the minCSA femoral neck section. Multivariate models accounting for height, weight, and age group (younger or older) showed that men had a 46% higher My and a 23% higher Fy than women, while women had a 13% thicker inferior cortex than men. Cortical thickness in the inferoposterior region of the femoral neck was significantly related to bending and axial strength after adjusting for overall volumetric bone mineral density. Both minCSA and IAP were higher in the older, gender-pooled age group, but Fy and My did not differ between the two age groups. The results suggest that age-related expansion of the femoral neck primarily occurs in the superior and inferior directions and helps maintain homeostasis of femoral neck stiffness and strength. The higher bending strength of the male femoral neck may partly explain why elderly men have a lower risk of hip fracture than elderly women.
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DOI：
10.1115/1.2895414
发表时间：
1991-11-01
影响因子：
1.7
作者：
ROBINOVITCH, SN;HAYES, WC;MCMAHON, TA
通讯作者：
MCMAHON, TA
影响因子：
4
作者：
Fox, KM;Cummings, SR;Stone, K
通讯作者：
Stone, K
影响因子：
6.2
作者：
Havill, Lorena M.;Mahaney, Michael C.;Specker, Bonny L.
通讯作者：
Specker, Bonny L.
影响因子：
4.1
作者：
Cheng, XG;Lowet, G;Dequeker, J
通讯作者：
Dequeker, J
影响因子：
56.9
作者：
HAYES, WC
通讯作者：
HAYES, WC