Correlates of SARS-CoV-2 anti-RBD IgG antibody titers among persons experiencing homelessness in Los Angeles.
Correlates of SARS-CoV-2 anti-RBD IgG antibody titers among persons experiencing homelessness in Los Angeles.
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DOI：
10.1111/phn.13170
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发表时间：
2023-05
影响因子：
2.1
通讯作者：
Messaoudi, Ilhem
中科院分区：
文献类型：
--
作者：
Nyamathi, Adeline;Shin, Sanghyuk S.;Doratt, Brianna M.;Jones-Patten, Alexandria;Salem, Benissa;Gelberg, Lillian;Lee, Darlene;Garfin, Dana;Yadav, Kartik;Chang, Alicia H.;White, Kathryn;Arce, Nicholas;Messaoudi, Ilhem
经历无家可归者（PEH）的人受到19日大流行的影响，这可能是由于慢性疾病，药物使用和心理健康状况的增加造成的脆弱性。
一项病例对照研究，以评估PEH中针对SARS-COV-2的抗体的存在以及与关键变量的关联。
洛杉矶Skid Row中的97 PEH的便利样本。
评估社会人口统计学，心理健康，药物和酒精使用，医疗保健访问，大流行压力以及其他COVID-19特定问题的结构化问卷。
我们发现，在15个PEH中有5个PEH中有5个未报告先前的COVID-19诊断或接种疫苗的15个PEH中的高抗受体结合结构域（RBD）IgG滴度，表明未诊断和/或无症状的COVID-19。虽然疫苗接种类别的抗RBD IgG滴度在统计学上没有显着意义（P = 0.069），但用Janssen疫苗接种的参与者的平均平均抗RBD IgG滴度最低。在多变量分析中，我们发现SARS-COV-2抗体滴度水平与Janssen疫苗和抑郁症之间存在负相关。因此，需要对PEH进行抑郁症和共同19岁的PEH的综合护理。
有必要进行进一步的研究，以确认对SARS-COV-2感染以及COVID-19疫苗接种的免疫反应，特别是在其免疫系统可能受到多种健康状况影响的PEH中。
People experiencing homelessness (PEH) have been especially impacted by the COVID-19 pandemic, likely due to increased vulnerabilities stemming from chronic diseases, substance use, and mental health conditions. A case-control study to assess the presence of antibodies against SARS-CoV-2 among PEH and associations with key variables. A convenience sample of 97 PEH in Skid Row, Los Angeles. A structured questionnaire assessing socio-demographic, mental health, drug and alcohol use, health care access, pandemic stress, and other COVID-19-specific questions. We found high anti-receptor binding domain (RBD) IgG titers among 5 of 15 PEH who reported no prior COVID-19 diagnosis or being vaccinated, suggesting undiagnosed and/or asymptomatic COVID-19. While anti-RBD IgG titers across vaccination categories were not statistically significant (P = 0.069), participants vaccinated with Janssen had the lowest mean anti-RBD IgG titers. In multivariable analysis, we found negative associations between level of SARS-CoV-2 antibody titers with the Janssen vaccine and depression; thus a need for integrated care for PEH with depression and COVID-19. Further research is warranted to confirm the immune response, initial and over time, to SARS-CoV-2 infection and to COVID-19 vaccinations, particularly among PEH whose immune systems may be impacted by multiple health conditions.
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