Regeneration Potential of Jellyfish: Cellular Mechanisms and Molecular Insights.
Regeneration Potential of Jellyfish: Cellular Mechanisms and Molecular Insights.
复制标题
水母的再生潜力：细胞机制和分子洞察。
DOI：
10.3390/genes12050758
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发表时间：
2021-05-17
期刊：
影响因子：
3.5
通讯作者：
Nakajima YI
中科院分区：
文献类型：
--
作者：
Fujita S;Kuranaga E;Nakajima YI
水母动物是刺胞动物亚门，具有多个生命阶段，包括无柄息肉和自由游泳的水母或水母，它们通常是钟形的凝胶状动物，表现出不同的形态。尽管拥有相对复杂的身体结构，肌肉和神经系统发育良好，但成年水母阶段保持了很高的再生能力，使器官再生以及从身体的一部分重建整个身体。水母这种非凡的再生潜力早已在不同物种中得到承认;然而，最近的研究已经开始解剖支撑再生事件的确切过程。在这篇文章中，我们介绍了目前对水母再生机制的理解，特别关注再生过程中的细胞行为，如伤口愈合，干/祖细胞形成芽基或细胞命运可塑性，以及恢复径向对称的生物体水平模式。我们还讨论了再生过程中涉及的假定分子机制，并介绍了各种新的模式水母物种，以了解复杂器官和整个身体再生的共同原则和不同机制。
Medusozoans, the Cnidarian subphylum, have multiple life stages including sessile polyps and free-swimming medusae or jellyfish, which are typically bell-shaped gelatinous zooplanktons that exhibit diverse morphologies. Despite having a relatively complex body structure with well-developed muscles and nervous systems, the adult medusa stage maintains a high regenerative ability that enables organ regeneration as well as whole body reconstitution from the part of the body. This remarkable regeneration potential of jellyfish has long been acknowledged in different species; however, recent studies have begun dissecting the exact processes underpinning regeneration events. In this article, we introduce the current understanding of regeneration mechanisms in medusae, particularly focusing on cellular behaviors during regeneration such as wound healing, blastema formation by stem/progenitor cells or cell fate plasticity, and the organism-level patterning that restores radial symmetry. We also discuss putative molecular mechanisms involved in regeneration processes and introduce a variety of novel model jellyfish species in the effort to understand common principles and diverse mechanisms underlying the regeneration of complex organs and the entire body.
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DOI：
10.1002/dvdy.24561
发表时间：
2018-03
期刊：
Developmental dynamics : an official publication of the American Association of Anatomists
影响因子：
--
作者：
Haensel D;Dai X
通讯作者：
Dai X
影响因子：
2.7
作者：
Deguchi, RU;Kondoh, E;Itoh, J
通讯作者：
Itoh, J
DOI：
10.1073/pnas.2.12.709
发表时间：
1916-01-01
影响因子：
11.1
作者：
Cary, LR
通讯作者：
Cary, LR
影响因子：
16.6
作者：
Brock, Courtney K.;Wallin, Stephen T.;Eisenhoffer, George T.
通讯作者：
Eisenhoffer, George T.
影响因子：
8.8
作者：
Genikhovich G;Fried P;Prünster MM;Schinko JB;Gilles AF;Fredman D;Meier K;Iber D;Technau U
通讯作者：
Technau U