Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?
Extracellular Vesicles in Osteosarcoma: Antagonists or Therapeutic Agents?
复制标题
DOI：
10.3390/ijms222212586
复制
发表时间：
2021-11-22
影响因子：
5.6
通讯作者：
Del Fattore A
中科院分区：
文献类型：
--
作者：
De Martino V;Rossi M;Battafarano G;Pepe J;Minisola S;Del Fattore A
骨肉瘤(OS)是一种主要影响儿童和青少年的骨骼肿瘤。远处转移是常见的，且好发于肺，是患者死亡的主要原因。治疗方法以手术和化疗为基础。然而，与化疗相关的耐药性和副作用需要确定新的治疗方法。了解骨肉瘤的复杂生物学场景将为确定其治疗的新靶点开辟道路。近年来，在肿瘤微环境中释放的细胞外小泡受到科学界的极大关注，它是肿瘤增殖和转移过程的重要调节因子。同时，循环细胞外小泡可以作为诊断和预后的生物标志物，并可以作为骨肉瘤患者的一种新的治疗方法。因此，OS相关EVS的特征可以代表一种将这些囊泡从对人类健康的拮抗剂转化为治疗和/或诊断试剂的方法。
Osteosarcoma (OS) is a skeletal tumor affecting mainly children and adolescents. The presence of distance metastasis is frequent and it is localized preferentially to the lung, representing the main reason for death among patients. The therapeutic approaches are based on surgery and chemotherapeutics. However, the drug resistance and the side effects associated with the chemotherapy require the identification of new therapeutic approaches. The understanding of the complex biological scenario of the osteosarcoma will open the way for the identification of new targets for its treatment. Recently, a great interest of scientific community is for extracellular vesicles (EVs), that are released in the tumor microenvironment and are important regulators of tumor proliferation and the metastatic process. At the same time, circulating extracellular vesicles can be exploited as diagnostic and prognostic biomarkers, and they can be loaded with drugs as a new therapeutic approach for osteosarcoma patients. Thus, the characterization of OS-related EVs could represent a way to convert these vesicles from antagonists for human health into therapeutic and/or diagnostic agents.
登录
查看更多内容
影响因子：
2.9
作者：
Celotti, F;Colciago, A;Sacchi, MC
通讯作者：
Sacchi, MC
癌症相关的间充质基质通过NF-κB激活对肿瘤内酸中毒的响应，促成骨肉瘤细胞的干性。
影响因子：
6.4
作者：
Avnet S;Di Pompo G;Chano T;Errani C;Ibrahim-Hashim A;Gillies RJ;Donati DM;Baldini N
通讯作者：
Baldini N
影响因子：
3.7
作者：
Corcoran C;Rani S;O'Brien K;O'Neill A;Prencipe M;Sheikh R;Webb G;McDermott R;Watson W;Crown J;O'Driscoll L
通讯作者：
O'Driscoll L
影响因子：
8.8
作者：
Chen X;Bahrami A;Pappo A;Easton J;Dalton J;Hedlund E;Ellison D;Shurtleff S;Wu G;Wei L;Parker M;Rusch M;Nagahawatte P;Wu J;Mao S;Boggs K;Mulder H;Yergeau D;Lu C;Ding L;Edmonson M;Qu C;Wang J;Li Y;Navid F;Daw NC;Mardis ER;Wilson RK;Downing JR;Zhang J;Dyer MA;St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
通讯作者：
St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
影响因子：
11.5
作者：
Baglio, S. Rubina;Lagerweij, Tonny;Pegtel, D. Michiel
通讯作者：
Pegtel, D. Michiel