Parallel 1024-ch Cyclic Voltammetry on Monolithic CMOS Electrochemical Detector Array
Parallel 1024-ch Cyclic Voltammetry on Monolithic CMOS Electrochemical Detector Array
复制标题
单片 CMOS 电化学检测器阵列上的并行 1024 通道循环伏安法
DOI：
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Brian N. Kim
中科院分区：
文献类型：
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作者：
Kevin A. White;Geoffrey Mulberry;Brian N. Kim
大规模微电极阵列在电生理学研究中提供了增强的时空分辨率。在本文中，我们讨论了一种能够进行1024通道并行循环伏安(CV)和其他电化学测量的电化学检测器阵列的设计和性能。该电化学检测器使用定制设计的芯片，集成了电路和片上微电极阵列，用于操作和记录电化学测量结果。针对并行1024通道记录，设计并集成了1024个基于电容的跨阻抗积分放大器(TIA)。TIA设计具有双极功能，可测量由于分子还原和氧化而产生的正负电化学电流。其动态范围为−700pa-1968pa。通过测量双电层电容，循环伏安可以用来检测电化学电极的质量。双电层电容形成于电极-电解液界面，是电极有效面积的函数。因此，被污染的电极可以具有较小的有效面积，从而产生较小的双电层电容。利用单片CMOS器件的并行循环电容能力，同时测量1024个电极的双层电容，实时检测电极表面的状态。电极阵列的初始测量显示平均电容为466pF。经过等离子体处理以去除电极表面的污染后，电容增加了1.36nF，几乎是有效表面积的三倍。我们利用单片CMOS传感器成功研制了1024路电化学探测器阵列。通过测量片上电极阵列的双层电容来验证循环伏安功能。这种方法可以在分析实验之前加速大量电极阵列的表征，以提供良好控制的电化学电极，这对于进行可靠的电化学测量是至关重要的。
Large-scale microelectrode arrays offers enhanced spatiotemporal resolution in electrophysiology studies.. In this paper, we discuss the design and performance of an electrochemical detector array which is capable of 1024-ch parallel cyclic voltammetry (CV) as well as other electrochemical measurements. The electrochemical detector is fabricated using a custom-designed CMOS chip which integrates both the circuity and on-chip microelectrode array, to operate and record from electrochemical measurements. For parallel 1024-ch recordings, 1024 capacitor-based integrating transimpedance amplifiers (TIA) are designed and integrated. The TIA design features the bipolar capabilities for measuring both negative and positive electrochemical currents due to reduction and oxidation of molecules. The resulted dynamic range of this TIA is −700 pA – 1968 pA. CV can be used to examine the quality of electrochemical electrodes by measuring the double-layer capacitance. Double-layer capacitance forms at the electrode-electrolyte interface and is a function of the effective area of the electrode. Thus, a contaminated electrode can have smaller effective area resulting in smaller double-layer capacitance. Using the parallel CV capability of the monolithic CMOS device, the double layer capacitance of all 1024 electrodes are simultaneously measured to examine the status of the electrodes’ surface in real time. The initial measurement of the electrode array showed a mean capacitance of 466 pF. After plasma treatment to remove contamination on the electrode’s surface, the increased capacitance was 1.36nF nearly tripling the effective surface area. We have successfully developed of 1024-ch electrochemical detector array using the monolithic CMOS sensor. The CV functionality was validated by measuring the double-layer capacitance of the on-chip electrode array. This method can accelerate the characterization of a massive electrode array before analytical experiments to provide well-controlled electrochemical electrodes, which is crucial in conducting reliable electrochemical measurements.
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DOI：
10.1039/c5ay00229j
发表时间：
2015-07-21
期刊：
Analytical methods : advancing methods and applications
影响因子：
--
作者：
Yao J;Liu XA;Gillis KD
通讯作者：
Gillis KD
影响因子：
12.6
作者：
Kim BN;Herbst AD;Kim SJ;Minch BA;Lindau M
通讯作者：
Lindau M
DOI：
10.1109/tbcas.2019.2897287
发表时间：
2019-04-01
影响因子：
5.1
作者：
Mulberry, Geoffrey;White, Kevin A.;Kim, Brian N.
通讯作者：
Kim, Brian N.
DOI：
10.1109/tbcas.2018.2861220
发表时间：
2018-12
影响因子：
5.1
作者：
White KA;Mulberry G;Smith J;Lindau M;Minch BA;Sugaya K;Kim BN
通讯作者：
Kim BN