Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients.
Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients.
复制标题
海洋来源和植物来源的omega-3多不饱和脂肪酸对2型糖尿病患者红细胞脂肪酸组成的影响
DOI：
10.1186/s12944-022-01630-0
复制
发表时间：
2022-02-10
影响因子：
4.5
通讯作者：
Sun G
中科院分区：
文献类型：
--
作者：
Liu H;Wang F;Liu X;Xie Y;Xia H;Wang S;Sun G
膳食脂肪酸摄入量影响红细胞脂肪酸组成，与糖脂代谢紊乱密切相关。本研究旨在探讨海洋和植物来源的omega-3多不饱和脂肪酸(n-3 PUFA)对2型糖尿病(T2 DM)患者红细胞脂肪酸和糖脂代谢的不同影响。对180例2型糖尿病患者进行了随机双盲试验。参与者被随机分配到三组进行为期六个月的干预。参与者被随机分配到三组进行为期六个月的干预。鱼油组给予含二十碳五烯酸和二十二碳六烯酸的鱼油3 g/d，紫苏油组给予3 g/d含α-亚麻酸(ALA)的鱼油，亚麻籽鱼油组给予亚麻籽和鱼油混合3 g/d。收集人口学资料，测量人体测量指标、糖脂代谢指标、红细胞脂肪酸组成。统计分析采用双因素方差分析。共有150名患者完成试验，其中FO组52例，PO组50例，LFO组48例。时间×治疗交互作用对空腹血糖、胰岛素、胰岛素抵抗指数、C肽、总胆固醇和甘油三酯水平有显著影响(P <； 0.001)。干预后PO、LFO组血糖、C-肽显著降低，FO组血清TG显著降低(P <； 0.001)。PO组红细胞C22：5、n-6、ALA、DPA、n-6/n-3PUFA、AA/EPA水平显著高于FO组和LFO组，而EPA、总n-3PUFA和Omega-3指数显著高于PO组。补充紫苏油可降低空腹血糖，补充鱼油可降低甘油三酯水平。海洋和植物来源的n-3多不饱和脂肪酸对红细胞的脂肪酸组成和调节糖脂代谢有不同的影响。本试验于2016年5月28日在中国临床试验注册中心登记(编号：CHICCTR-IOR-16008435)。
Dietary fatty acids intake affects the composition of erythrocyte fatty acids, which is strongly correlated with glycolipid metabolism disorders. This study aimed at investigating the different effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acid (n-3 PUFA) on the fatty acids of erythrocytes and glycolipid metabolism in patients with type 2 diabetes mellitus (T2DM). The randomized double-blinded trial that was performed on 180 T2DM patients. The participants were randomly assigned to three groups for the six-month intervention. The participants were randomly assigned to three groups for the six-month intervention. The fish oil (FO) group was administered with FO at a dose of 3 g/day containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), the perilla oil (PO) group was administered with PO at a dose of 3 g/day containing α-linolenic (ALA), the linseed and fish oil (LFO) group was administered with mixed linseed and fish oil at a dose of 3 g/day containing EPA, DHA and ALA. Demographic information were collected and anthropometric indices, glucose and lipid metabolism indexes, erythrocyte fatty acid composition were measured. Statistical analyses were performed using two-way ANOVA. A total of 150 patients finished the trial, with 52 of them in the FO group, 50 in the PO group and 48 in the LFO group. There were significant effects of time × treatment interaction on fast blood glucose (FBG), insulin, HOMA-IR and C-peptide, TC and triglyceride (TG) levels (P < 0.001). Glucose and C-peptide in PO and LFO groups decreased significantly and serum TG in FO group significantly decreased (P < 0.001) after the intervention. Erythrocyte C22: 5 n-6, ALA, DPA, n-6/n-3 PUFA, AA/EPA levels in the PO group were significantly higher than FO and LFO groups, while EPA, total n-3 PUFA and Omega-3 index were significantly higher in the FO and LFO groups compared to PO group. Supplementation with perilla oil decreased FBG while fish oil supplementation decreased the TG level. Marine-based and plant-based n-3 PUFAs exhibit different effects on fatty acid compositions of erythrocytes and regulated glycolipid metabolism. This trial was recorded under Chinese Clinical Trial Registry Center (NO: ChiCTR-IOR-16008435) on May 28 2016.
登录
查看更多内容
影响因子：
3.7
作者：
Harris WS;Luo J;Pottala JV;Margolis KL;Espeland MA;Robinson JG
通讯作者：
Robinson JG
DOI：
10.1016/j.plefa.2006.12.003
发表时间：
2007-03-01
影响因子：
3
作者：
Decsi, T.;Szabo, E.;Soltesz, Gy.
通讯作者：
Soltesz, Gy.
影响因子：
15.8
作者：
Forouhi NG;Imamura F;Sharp SJ;Koulman A;Schulze MB;Zheng J;Ye Z;Sluijs I;Guevara M;Huerta JM;Kröger J;Wang LY;Summerhill K;Griffin JL;Feskens EJ;Affret A;Amiano P;Boeing H;Dow C;Fagherazzi G;Franks PW;Gonzalez C;Kaaks R;Key TJ;Khaw KT;Kühn T;Mortensen LM;Nilsson PM;Overvad K;Pala V;Palli D;Panico S;Quirós JR;Rodriguez-Barranco M;Rolandsson O;Sacerdote C;Scalbert A;Slimani N;Spijkerman AM;Tjonneland A;Tormo MJ;Tumino R;van der A DL;van der Schouw YT;Langenberg C;Riboli E;Wareham NJ
通讯作者：
Wareham NJ
影响因子：
158.5
作者：
Ali, Mohammed K.;Bullard, Kai McKeever;Gregg, Edward W.
通讯作者：
Gregg, Edward W.
影响因子：
8.2
作者：
Harris, Katie;Oshima, Megumi;Woodward, Mark
通讯作者：
Woodward, Mark