Therapeutic role of curcumin and its novel formulations in gynecological cancers.
Therapeutic role of curcumin and its novel formulations in gynecological cancers.
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DOI：
10.1186/s13048-020-00731-7
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发表时间：
2020-11-04
影响因子：
4
通讯作者：
Mirzaei H
中科院分区：
文献类型：
--
作者：
Pourhanifeh MH;Darvish M;Tabatabaeian J;Fard MR;Mottaghi R;Azadchehr MJ;Jahanshahi M;Sahebkar A;Mirzaei H
妇科癌症是全球癌症相关死亡的主要原因之一。虽然病例数量正在上升，但目前的治疗方法不够有效。有相当大的副作用以及治疗耐药类型。此外，这些都使患者的治疗变得复杂。因此，为了提高治疗过程的疗效和患者的生活质量，寻找新的辅助治疗方法是非常有必要的。姜黄素是一种很有前途的天然化合物，具有多种治疗潜力，包括显著的抗癌作用。近年来，各种研究已经证明了姜黄素及其新型类似物对妇科癌症的抗癌作用。此外，姜黄素的新配方已经产生了进一步的有利作用。这篇综述讨论了这些研究，并强调了观察到的效应可能的潜在机制。
Gynecological cancers are among the leading causes of cancer-associated mortality worldwide. While the number of cases are rising, current therapeutic approaches are not efficient enough. There are considerable side-effects as well as treatment resistant types. In addition, which all make the treatment complicated for afflicted cases. Therefore, in order to improve efficacy of the treatment process and patients’ quality of life, searching for novel adjuvant treatments is highly warranted. Curcumin, a promising natural compound, is endowed with numerous therapeutic potentials including significant anticancer effects. Recently, various investigations have demonstrated the anticancer effects of curcumin and its novel analogues on gynecological cancers. Moreover, novel formulations of curcumin have resulted in further propitious effects. This review discusses these studies and highlights the possible underlying mechanisms of the observed effects.
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影响因子：
12.8
作者：
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通讯作者：
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影响因子：
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影响因子：
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作者：
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DOI：
10.1016/j.nano.2019.03.011
发表时间：
2019-07-01
影响因子：
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作者：
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Alani, Adam W. G.