Emerging Therapeutics to Overcome Chemoresistance in Epithelial Ovarian Cancer: A Mini-Review.
Emerging Therapeutics to Overcome Chemoresistance in Epithelial Ovarian Cancer: A Mini-Review.
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DOI：
10.3390/ijms18102171
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发表时间：
2017-10-18
影响因子：
5.6
通讯作者：
Landen CN
中科院分区：
文献类型：
--
作者：
Cornelison R;Llaneza DC;Landen CN
卵巢癌是女性癌症死亡的第五大原因，也是最致命的妇科恶性肿瘤。高级别浆液性卵巢癌(HGSOC)的主要死亡原因之一是化疗耐药疾病，这种疾病可能表现为对治疗的固有或获得性耐药。在这里，我们讨论了一些已知的在卵巢癌化疗耐药中被详尽研究的分子机制，包括药物外排泵多药耐药蛋白1(MDR1)、上皮-间充质转化、DNA损伤和修复能力。我们还讨论了新的治疗方法，可能会解决一些挑战，将针对化疗耐药过程的方法从长凳带到床边。其中一些新疗法包括新的药物输送系统，可能阻止肿瘤适应性变化的靶点，利用使癌细胞容易受到不可逆转损害的肿瘤突变，以及针对核糖体生物发生的新药，这一过程在癌症和非癌症细胞中可能是独特的不同。这些方法中的每一种，或它们的组合，都可能为更广泛的HGSOC患者提供更多的积极结果。
Ovarian cancer is the fifth leading cause of cancer death among women and the most lethal gynecologic malignancy. One of the leading causes of death in high-grade serous ovarian cancer (HGSOC) is chemoresistant disease, which may present as intrinsic or acquired resistance to therapies. Here we discuss some of the known molecular mechanisms of chemoresistance that have been exhaustively investigated in chemoresistant ovarian cancer, including drug efflux pump multidrug resistance protein 1 (MDR1), the epithelial–mesenchymal transition, DNA damage and repair capacity. We also discuss novel therapeutics that may address some of the challenges in bringing approaches that target chemoresistant processes from bench to bedside. Some of these new therapies include novel drug delivery systems, targets that may halt adaptive changes in the tumor, exploitation of tumor mutations that leave cancer cells vulnerable to irreversible damage, and novel drugs that target ribosomal biogenesis, a process that may be uniquely different in cancer versus non-cancerous cells. Each of these approaches, or a combination of them, may provide a greater number of positive outcomes for a broader population of HGSOC patients.
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DOI：
10.1038/nrc2644
发表时间：
2009-06
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
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影响因子：
82.9
作者：
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影响因子：
6.4
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Taubert, H
影响因子：
10.6
作者：
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Chow EK
DOI：
10.1038/nrc4019
发表时间：
2015-11
期刊：
Nature reviews. Cancer
影响因子：
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作者：
Bowtell DD;Böhm S;Ahmed AA;Aspuria PJ;Bast RC Jr;Beral V;Berek JS;Birrer MJ;Blagden S;Bookman MA;Brenton JD;Chiappinelli KB;Martins FC;Coukos G;Drapkin R;Edmondson R;Fotopoulou C;Gabra H;Galon J;Gourley C;Heong V;Huntsman DG;Iwanicki M;Karlan BY;Kaye A;Lengyel E;Levine DA;Lu KH;McNeish IA;Menon U;Narod SA;Nelson BH;Nephew KP;Pharoah P;Powell DJ Jr;Ramos P;Romero IL;Scott CL;Sood AK;Stronach EA;Balkwill FR
通讯作者：
Balkwill FR