Phenols, quinolines, indoles, benzene, and 2-cyclopenten-1-ones are oviductal toxicants in cigarette smoke.
Phenols, quinolines, indoles, benzene, and 2-cyclopenten-1-ones are oviductal toxicants in cigarette smoke.
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苯酚、喹啉、吲哚、苯和 2-环戊烯-1-酮是香烟烟雾中的输卵管毒物。
DOI：
10.1093/toxsci/kfi112
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
Talbot,P
中科院分区：
文献类型：
--
作者：
Riveles,Karen;Roza,R;Talbot,P
以前，我们发现香烟烟雾中的吡啶类和吡嗪类药物在纳摩尔和皮摩尔剂量下抑制输卵管功能。本研究的目的是使用仓鼠输卵管确定主流烟雾溶液中发现的酚类、喹啉类、吲哚类、苯和2-环戊烯-1-酮对纤毛搏动频率、卵母细胞拾取率和漏斗平滑肌收缩的最低可观察不良作用水平（LOAEL）。固相萃取后，主流烟雾溶液馏分进行了测试，输卵管测定。使用气相色谱-质谱法分析活性组分以鉴定单个化学物质。使用这种方法，苯，11酚，吲哚，两个喹啉，和两个2-环戊烯-1-酮衍生物中的活性馏分。在仓鼠输卵管的剂量-反应研究中测试了所鉴定化合物的市售真实标准品。使用纤毛搏动频率、卵母细胞拾取率和漏斗平滑肌收缩率测定确定每种化合物的LOAEL。吲哚是效力最高的化合物，在飞摩尔剂量下，表现出对纤毛搏动频率（10− 13 M）、卵母细胞拾取率（10− 14 M）和漏斗平滑肌收缩率（10− 15 M）的抑制作用。所有其他测试的化合物，除了苯酚，其仅在毫摩尔浓度下显示抑制作用，在皮摩尔、纳摩尔或微摩尔浓度下均具有抑制作用。苯酚的衍生化增加了其在输卵管试验中的毒性，特别是当甲基或乙基基团被取代的第四位。吲哚类、喹啉类和四种酚类化合物在输卵管试验中具有高效力和有效性。
Previously, we showed that pyridines and pyrazines in cigarette smoke inhibit oviductal functioningin vitroin nanomolar and picomolar doses. The purpose of this study was to determine the lowest observable adverse effect levels (LOAELs) of phenols, quinolines, indoles, benzene, and 2-cyclopenten-1-ones found in mainstream smoke solutions on ciliary beat frequency, oocyte pickup rate, and infundibular smooth muscle contraction using the hamster oviduct. After solid phase extraction, mainstream smoke solution fractions were tested in the oviductal assays. The active fractions were analyzed using gas chromatography-mass spectrometry to identify individual chemicals. Using this approach, benzene, eleven phenolic, two indole, two quinoline, and two 2-cyclopenten-1-one derivatives were identified in the active fractions. Commercially available authentic standards of the identified compounds were tested in dose-response studies on hamster oviducts. The LOAELs were determined for each compound using the ciliary beat frequency, oocyte pickup rate, and infundibular smooth muscle contraction rate assays. Indole, the compound with the highest potency, showed inhibition of ciliary beat frequency (10−13M), oocyte pickup rate (10−14M), and infundibular smooth muscle contraction rate (10−15M) in femtomolar doses. All of the other compounds tested, except phenol, which only showed inhibition at millimolar concentrations, were inhibitory in picomolar, nanomolar, or micromolar concentrations. Derivitization of phenol increased its toxicity in the oviductal assays, especially when a methyl or ethyl group was substituted on the fourth position. The indoles, quinolines, and four phenolic compounds had both high potencies and efficacies in the oviductal assays.
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因主动和被动吸烟而接触苯和其他挥发性化合物。
DOI：
--
发表时间：
1987
期刊：
Archives of Environmental Health An International Journal
影响因子：
--
作者：
L. Wallace;E. Pellizzari;T. Hartwell;R. Perritt;R. Ziegenfus
通讯作者：
R. Ziegenfus
影响因子：
5.5
作者：
Castles, A;Adams, EK;Boulton, ML
通讯作者：
Boulton, ML
影响因子：
5.1
作者：
C. Selassie;T. DeSoyza;M. Rosario;H. Gao;C. Hansch
通讯作者：
C. Selassie;T. DeSoyza;M. Rosario;H. Gao;C. Hansch
吸烟和肾上腺素（肾上腺素）对子宫输卵管充气试验（鲁宾试验）的影响。
影响因子：
6.7
作者：
Alexander Neri;Benjamin Eckerling
通讯作者：
Benjamin Eckerling
一系列对位取代酚的体外胚胎毒性：结构、活性以及与体内数据的相关性。
DOI：
--
发表时间：
1992
期刊：
Teratology
影响因子：
--
作者：
Linda A. Oglesby;Marian T. Ebron;Tina R. Logsdon;Frank Copeland;P. E. Beyer;R. Kavlock
通讯作者：
R. Kavlock