Effect of Late Androgen Replacement Therapy on Erectile Function Through Structural Changes in Castrated Rats.
Effect of Late Androgen Replacement Therapy on Erectile Function Through Structural Changes in Castrated Rats.
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DOI：
10.1016/j.esxm.2021.100348
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发表时间：
2021-08
期刊：
影响因子：
2.6
通讯作者：
Kimura K
中科院分区：
文献类型：
--
作者：
Kataoka T;Hotta Y;Yamamoto Y;Fukamoto A;Takeuchi M;Maeda Y;Kimura K
由于雄激素替代疗法（ART）在雄激素缺乏发生后未立即实施，该治疗被认为是延迟的。
为了研究在大鼠去势4周后开始的延迟雄激素替代疗法对勃起功能以及海绵体结构变化的影响。
大鼠接受雄激素替代疗法4周（延迟雄激素替代疗法[4周]）或8周（延迟雄激素替代疗法[8周]）。在这两种情况下，大鼠被分为以下几组：去势组（Cast）、去势后皮下注射睾酮（3mg/kg/天；Cast + T）组以及假手术组（Sham）。Cast + T组大鼠在去势4周后开始每日皮下注射睾酮，持续4周或8周，而Sham组和Cast组大鼠仅给予赋形剂。
通过评估海绵体神经电刺激后的海绵体内压（ICP）和平均动脉压（MAP）、使用动态灌注海绵体测压法评估海绵体静脉闭塞功能以及使用Masson三色染色法进行组织学评估来评估勃起功能。
在延迟雄激素替代疗法（4周）组的Cast + T大鼠中未观察到ICP升高（0.47 ± 0.02，P > 0.05），然而，在延迟雄激素替代疗法（8周）组的Cast + T大鼠中，ICP/MAP比值（0.60 ± 0.02，P < 0.05）、下降率以及平滑肌/胶原比值均显著升高。
本研究为延迟雄激素替代疗法对勃起功能的影响提供了科学依据。
本研究通过海绵体结构的改善深入了解了延迟雄激素替代疗法对勃起功能的影响。本研究的主要局限性在于人与大鼠愈合所需时间的差异，这可能对结果的转化相关性产生影响。
延迟雄激素替代疗法可以改善勃起功能。然而，由于改善需要相当长的时间，为了获得最佳效果，有必要耐心地坚持治疗。
片冈T，堀田Y，山本Y等。延迟雄激素替代疗法通过去势大鼠结构变化对勃起功能的影响。《性医学》2021；XX：XX - XXX
Because androgen replacement therapy (ART) is not performed immediately after the onset of androgen deficiency, the treatment is considered to be late. To investigate the effects of late ART, starting 4 weeks after castration of rats, on erectile function and structural changes in the corpus cavernosum. Rats were subjected to ART for 4 (Late-ART [4w]) or 8 (Late-ART [8w]) weeks. In either case, rats were assigned to the following groups: castrated (Cast), castrated with subcutaneous administration of testosterone (3 mg/kg/day; Cast+T), and sham (Sham). Cast + T rats received daily subcutaneous doses of testosterone starting 4 weeks after castration for 4 or 8 weeks whereas Sham and Cast rats received only the vehicle. Erectile function was assessed by evaluating intracavernosal pressure (ICP) and mean arterial pressure (MAP) after electrical stimulation of the cavernous nerve, corporal veno-occlusive function using dynamic infusion cavernosometry, and histology using Masson's trichrome staining. No increase in the ICP was observed in Cast+T rats in the Late-ART (4w) group (0.47 ± 0.02, P > .05), whereas, in Cast+T rats in the Late-ART (8w) group, there was a significant increase in the ICP/MAP ratio (0.60 ± 0.02, P < .05), drop rate, and smooth muscle/collagen ratio. The present study provides scientific evidence for the effect of late ART on erectile function. This study provides insights into the influence of late ART on erectile function through improvements in the structure of corpus cavernosum. The major limitation of this study is the difference in the time required for healing between the humans and rats, which might have a bearing on the translational relevenace of the results. Late ART could improve erectile function. However, as improvement requires a considerable time period, it is necessary to persist with therapy patiently for optimal results. Kataoka T, Hotta Y, Yamamoto Y, et al. Effect of Late Androgen Replacement Therapy on Erectile Function Through Structural Changes in Castrated Rats. Sex Med 2021;XX:XX–XXX.
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