Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.
Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood.
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DOI：
10.1111/adb.12066
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发表时间：
2014-11
影响因子：
3.4
通讯作者：
Kuperman S
中科院分区：
文献类型：
--
作者：
Dick DM;Cho SB;Latendresse SJ;Aliev F;Nurnberger JI Jr;Edenberg HJ;Schuckit M;Hesselbrock VM;Porjesz B;Bucholz K;Wang JC;Goate A;Kramer JR;Kuperman S
纵向分析使我们能够了解遗传风险如何在整个发育过程中展开，这是对不同年龄个体进行横断面分析所不可能做到的。这在遗传关联分析中很少受到关注。在这项研究中，我们测试了GABRA 2（一种以前与酒精依赖相关的基因）对14至25岁醉酒轨迹的遗传影响。我们使用了来自1070名参与酒精中毒遗传学合作研究（COGA）前瞻性样本的个人的数据，以便更好地了解遗传风险在整个发育过程中的表现。分段线性增长模型拟合了基因型对从青春期早期到青年期（14-18岁）的醉酒增加率、向成年期过渡期间（18-19岁）的醉酒变化以及青年期（≥ 19岁）的醉酒变化率的影响。GABRA 2的变化与青少年和成年人之间过渡期的醉酒增加有关。基因型效应在女性中更为明显。这些分析说明了纵向数据的重要性，以描述遗传效应如何在整个发展过程中展开。研究结果表明，重要发育时期的过渡可能会改变遗传效应对酒精使用模式的相对重要性。研究结果还表明，在评估遗传对男性和女性饮酒模式的影响时，考虑性别的重要性。
Longitudinal analyses allow us to understand how genetic risk unfolds across development, in a way that is not possible with cross-sectional analyses of individuals at different ages. This has received little attention in genetic association analyses. In this study, we test for genetic effects of GABRA2, a gene previously associated with alcohol dependence, on trajectories of drunkenness from age 14 to 25. We use data from 1070 individuals who participated in the prospective sample of the Collaborative Study on the Genetics of Alcoholism (COGA), in order to better understand the unfolding of genetic risk across development. Piecewise linear growth models were fit to model the influence of genotype on rate of increase in drunkenness from early adolescence to young adulthood (14–18 years), the change in drunkenness during the transition to adulthood (18–19 years), and the rate of change in drunkenness across young adulthood (≥ 19 years). Variation in GABRA2 was associated with an increase in drunkenness that occurred at the transition between adolescence and adulthood. The genotypic effect was more pronounced in females. These analyses illustrate the importance of longitudinal data to characterize how genetic effects unfold across development. The findings suggest that transitions across important developmental periods may alter the relative importance of genetic effects on patterns of alcohol use. The findings also suggest the importance of considering gender when evaluating genetic effects on drinking patterns in males and females.
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影响因子：
9.8
作者：
Edenberg, HJ;Dick, DM;Begleiter, H
通讯作者：
Begleiter, H
影响因子：
4.5
作者：
Chahrour MH;Yu TW;Lim ET;Ataman B;Coulter ME;Hill RS;Stevens CR;Schubert CR;ARRA Autism Sequencing Collaboration;Greenberg ME;Gabriel SB;Walsh CA
通讯作者：
Walsh CA
DOI：
10.1111/j.1530-0277.2010.01156.x
发表时间：
2010-05
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Edenberg HJ;Koller DL;Xuei X;Wetherill L;McClintick JN;Almasy L;Bierut LJ;Bucholz KK;Goate A;Aliev F;Dick D;Hesselbrock V;Hinrichs A;Kramer J;Kuperman S;Nurnberger JI Jr;Rice JP;Schuckit MA;Taylor R;Todd Webb B;Tischfield JA;Porjesz B;Foroud T
通讯作者：
Foroud T
DOI：
10.1002/ajmg.b.30091
发表时间：
2004-08-15
影响因子：
2.8
作者：
Covault, J;Gelernter, J;Kranzler, HR
通讯作者：
Kranzler, HR
影响因子：
2.6
作者：
Dick, DM;Aliev, F;Hesselbrock, V
通讯作者：
Hesselbrock, V