Alcohol dose effects on stress response to cued threat vary by threat intensity.
Alcohol dose effects on stress response to cued threat vary by threat intensity.
复制标题
酒精剂量对对提示威胁的压力反应的影响因威胁强度而异。
DOI：
10.1007/s00213-011-2304-6
复制
发表时间：
2011-11
影响因子：
3.4
通讯作者：
Curtin, John J.
中科院分区：
文献类型：
--
作者：
Moberg, Christine A.;Weber, Stefanie M.;Curtin, John J.
关键词：
澄清酒精对威胁期间应激反应的影响对于理解酒精使用的动机和相关的酒精使用障碍至关重要。酒精的应激反应抑制（SRD）的影响的评价一直受到限制，非系统地使用各种实验方法和措施。本实验参数变化的酒精剂量和休克威胁强度之间的社会饮酒者，以检查他们的影响惊吓增强，一种生理措施的情感成分的压力反应。96名参与者被分配到四个饮料组之一：安慰剂组和目标血液酒精浓度（BAC）为0.04%、0.075%和0.11%的组。参与者观看了电击和非电击块中的彩色线索。不同颜色的线索预测即将到来的低，中，或高强度电击管理。电击威胁时惊吓增强与无电击提示时的情感反应。高威胁增加惊吓增强相对于中等/低强度的威胁。惊吓增强随BAC增加而降低。威胁强度缓和了这种BAC效应，在高威胁期间观察到最强的BAC效应。对个体差异调节因子的分析显示，BAC在较重、问题较多的饮酒者中的作用降低。观察到明确的酒精SRD效应。这些SRD效应在较高的BAC和更强的威胁期间最大。未能解释这些因素可能部分解释不一致的结果，在过去的实验室SRD研究。此外，他们建议在更高剂量和更大压力的个体中，酒精的强化作用更大。饮酒和问题对SRD影响的适度指向可能的重要风险因素。
Clarification of alcohol’s effect on stress response during threat is critical to understand motivation for alcohol use and related alcohol-use disorders. Evaluation of stress response dampening (SRD) effects of alcohol has been limited by nonsystematic use of varied experimental methods and measures. This experiment parametrically varied alcohol dose and shock threat intensity among social drinkers to examine their effects on startle potentiation, a physiological measure of the affective component of the stress response. 96 participants were assigned to one of four beverage groups: placebo and target blood alcohol concentration (BAC) groups of 0.04, 0.075, and 0.11%. Participants viewed colored cues presented in shock and no-shock blocks. Distinct colored cues predicted imminent low, moderate, or high intensity electric shock administration. Startle potentiation during shock threat relative to no-shock cues indexed affective response. High threat increased startle potentiation relative to moderate/low intensity threat. Startle potentiation decreased as BAC increased. Threat intensity moderated this BAC effect with the strongest BAC effect observed during high threat. Analysis of individual difference moderators revealed reduced effect of BAC among heavier, more problematic drinkers. Clear alcohol SRD effects were observed. These SRD effects were greatest at higher BACs and during more potent threat. Failure to account for these factors may partially explain inconsistent findings in past laboratory SRD research. Furthermore, they suggest greater reinforcement from alcohol at higher doses and among individuals with greater stress. Moderation of SRD effects by alcohol consumption and problems point to possible important risk factors.
登录
查看更多内容
在大鼠和人类中持续的恐惧：恐惧与焦虑中的杏仁核的作用。
DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.4
作者：
Baas, JMP;Grillon, C;Verbaten, MN
通讯作者：
Verbaten, MN
影响因子：
5.9
作者：
CHRISTIANSEN, BA;GOLDMAN, MS;INN, A
通讯作者：
INN, A
影响因子：
10.6
作者：
Grillon, Christian;Baas, Johanna M. P.;Levine, Jessica
通讯作者：
Levine, Jessica
影响因子：
3
作者：
Croissant, Bernhard;Rist, Fred;Olbrich, Robert
通讯作者：
Olbrich, Robert