Progress and applications of mass cytometry in sketching immune landscapes.
Progress and applications of mass cytometry in sketching immune landscapes.
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质谱流式技术在绘制免疫图谱方面的进展和应用
DOI：
10.1002/ctm2.206
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发表时间：
2020-10
影响因子：
10.6
通讯作者：
Ding X
中科院分区：
文献类型：
--
作者：
Zhang T;Warden AR;Li Y;Ding X
Recently emerged mass cytometry (cytometry by time‐of‐flight [CyTOF]) technology permits the identification and quantification of inherently diverse cellular systems, and the simultaneous measurement of functional attributes at the single‐cell resolution. By virtue of its multiplex ability with limited need for compensation, CyTOF has led a critical role in immunological research fields. Here, we present an overview of CyTOF, including the introduction of CyTOF principle and advantages that make it a standalone tool in deciphering immune mysteries. We then discuss the functional assays, introduce the bioinformatics to interpret the data yield via CyTOF, and depict the emerging clinical and research applications of CyTOF technology in sketching immune landscape in a wide variety of diseases. 1. The CyTOF technique enables immune profiling of various disease conditions. 2. The development of CyTOF‐based functional assays and bioinformatics pipelines is thriving and promising. 3. CyTOF may serve as a promising platform to facilitate the identification of immunological biomarkers and drug screening.
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影响因子：
46.9
作者：
Becht, Etienne;McInnes, Leland;Newell, Evan W.
通讯作者：
Newell, Evan W.
影响因子：
16.8
作者：
Bendall SC;Nolan GP;Roederer M;Chattopadhyay PK
通讯作者：
Chattopadhyay PK
影响因子：
22.7
作者：
Ali, H. Raza;Jackson, Hartland W.;Bodenmiller, Bernd
通讯作者：
Bodenmiller, Bernd
影响因子：
8.8
作者：
An Y;Adams JR;Hollern DP;Zhao A;Chang SG;Gams MS;Chung PED;He X;Jangra R;Shah JS;Yang J;Beck LA;Raghuram N;Kozma KJ;Loch AJ;Wang W;Fan C;Done SJ;Zacksenhaus E;Guidos CJ;Perou CM;Egan SE
通讯作者：
Egan SE
DOI：
10.1073/pnas.1711365115
发表时间：
2018-05-01
影响因子：
11.1
作者：
Anchang B;Davis KL;Fienberg HG;Williamson BD;Bendall SC;Karacosta LG;Tibshirani R;Nolan GP;Plevritis SK
通讯作者：
Plevritis SK