Strong association between pseudogenization mechanisms and gene sequence length.

Strong association between pseudogenization mechanisms and gene sequence length.
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伪施加机制与基因序列长度之间的密切关联。

DOI:
10.1186/1745-6150-4-38
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发表时间:
2009-10-06
期刊:
影响因子:
5.5
通讯作者:
Harrison PM
Harrison PM
中科院分区:
生物学2区
文献类型:
--
作者:
Khachane AN;Harrison PM

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假基因产生于rna介导的复制(加工过的假基因)或dna介导的复制(未加工过的假基因)后基因拷贝的衰变。在这里,我们表明,较长的蛋白质编码基因倾向于产生更多的未经加工的假基因比短的基因,而相反的是正确的加工假基因。长度超过3000 bp的蛋白质编码基因产生未经加工的假基因的可能性是经过加工的假基因的6倍。本文由Dan Graur博士和Craig Nelson博士(由J Peter Gogarten博士提名)审阅。
Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the opposite is true for processed pseudogenes. Protein-coding genes longer than 3000 bp are 6 times more likely to produce nonprocessed pseudogenes than processed ones. This article was reviewed by Dr. Dan Graur and Dr. Craig Nelson (nominated by Dr. J Peter Gogarten).
DOI: 10.1093/nar/gkh605
发表时间: 2004-06-01
影响因子: 14.9
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发表时间: 2009-09-15
期刊: BMC genomics
影响因子: 4.4
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