Regulation of nutrient transporters by metabolic and environmental stresses.

Regulation of nutrient transporters by metabolic and environmental stresses.
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DOI:
10.1016/j.ceb.2020.02.009
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发表时间:
2020-08
影响因子:
7.5
通讯作者:
Babst M
Babst M
中科院分区:
生物学2区
文献类型:
--
作者:
Babst M

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酵母质膜是不稳定环境和细胞代谢之间的选择性屏障。营养转运蛋白是控制进入代谢途径的分子输入的守门人。营养物质的输入迅速调整代谢和环境的变化,这是通过调节转运蛋白的表面表达来完成的。最近的研究表明,脂质环境中的转运功能调节泛素化效率和这些蛋白质的内吞作用。脂质环境的变化是由转运蛋白在不同膜结构域之间的横向运动和细胞外环境对质膜流动性的影响引起的。
The yeast plasma membrane is a selective barrier between an erratic environment and the cell’s metabolism. Nutrient transporters are the gatekeepers that control the import of molecules feeding into the metabolic pathways. Nutrient import adjusts rapidly to changes in metabolism and the environment, which is accomplished by regulating the surface expression of transporters. Recent studies indicate that the lipid environment in which transporters function regulates ubiquitination efficiency and endocytosis of these proteins. Changes in the lipid environment are caused by lateral movements of the transporters between different membrane domains and by the influence of the extracellular environment on the fluidity of the plasma membrane.
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