Embryonic ventricular diastolic and systolic pressure-volume relations
Embryonic ventricular diastolic and systolic pressure-volume relations
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胚胎心室舒张压和收缩压-容积关系
DOI：
10.1017/s1047951100010829
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发表时间：
1994
影响因子：
1
通讯作者：
N. Hu
中科院分区：
文献类型：
--
作者：
B. Keller;J. P. Tinney;N. Hu
在心血管发育过程中，胚胎心脏和血管床动态地相互作用以支持胚胎的快速生长。压力-容积关系定义了负荷条件改变时的心室功能。我们分析了胚胎心脏中的这些关系，以确定心室功能以及心室和血管床对前负荷急性变化的反应。我们同时测量心室压力，并记录60个视频图像每秒n≥6阶段16，18和21白色来航鸡胚胎在基线和1-2微升的生理缓冲液注入静脉窦（窦静脉）。然后局部应用2摩尔氯化钠诱导室性手足抽搐。追踪心室压力和心外膜横截面积的视频场。假设椭圆体几何形状，将横截面积转换为体积，并将腔体积计算为总体积减去来自强直心脏的壁体积。我们定义了心室收缩开始时的舒张末期和最大压力/容积比时的收缩末期。每搏输出量随舒张末期容积线性增加。舒张末期压力-容积关系为正的线性关系，收缩末期压力-容积关系为向下的曲线关系。动脉弹性随胚胎生长和输注量的增加而降低。压力-容积环面积是能量消耗的一个指标，在胚胎阶段之间翻了一番。因此，胚胎心室压力-容积关系定义了静息时和对改变的前负荷的反应时的舒张和收缩功能。
Summary The embryonic heart and vascular bed interact dynamically to support rapid growth of the embryo during cardiovascular development. Pressure-volume relations define ventricular function during alterations in loading conditions. We analyzed these relationships in the embryonic heart in order to define ventricular function and the response of the ventricle and vascular bed to acute changes in preload. We simultaneously measured ventricular pressure and recorded 60 video images per second in n≥6 stage 16, 18 and 21 white Leghorn chick embryos at baseline and during the infusion of 1–2 microliters of physiologic buffer into the venous sinus (sinus venosus). Ventricular tetany was then induced with the topical application of 2 Molar sodium chloride. Video fields were traced for ventricular pressure and epicardial cross-sectional area. Cross-sectional area was converted to volume assuming ellipsoid geometry, and cavity volume was calculated as total volume minus wall volume derived from the tetanized heart. We defined end-diastole at the onset of ventricular contraction and end-systole at maximum pressure/volume ratio. Stroke volume increased linearly with end-diastolic volume. End-diastolic pressure-volume relations were positive and linear, and end-systolic pressure-volume relations were curvilinear downward. Arterial elastance decreased with growth of the embryo and with volume infusion. Pressure-volume loop area, an index of consumption of energy, doubled between the embryonic stages. Thus, embryonic ventricular pressure-volume relations define diastolic and systolic function at rest and in response to altered preload.
长期维拉帕米治疗对鸡胚胎心室功能和生长的影响。
DOI：
10.1152/ajpheart.1991.261.1.h166
发表时间：
1991
期刊：
The American journal of physiology
影响因子：
--
作者：
Clark,EB;Hu,N;Turner,DR;Litter,JE;Hansen,J
通讯作者：
Hansen,J