Regional expression of MTG genes in the developing mouse central nervous system.
Regional expression of MTG genes in the developing mouse central nervous system.
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DOI：
10.1002/dvdy.22021
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发表时间：
2009-08
影响因子：
2.5
通讯作者：
Nakagawa, Yasushi
中科院分区：
文献类型：
--
作者：
Alishahi, Amin;Koyano-Nakagawa, Naoko;Nakagawa, Yasushi
关键词：
MTG8MTG16MTGR1CBFA2T1CBFA2T2CBFA2T3ETOETO-2ETO-REHTNeurog2Ngn2NeurogeninAscl1Mash1achaete-scute homologneurogenesisdifferentiationneuronal progenitorspinal cordtelencephalondiencephalonthalamusretinacentral nervous systemCNSlineage tracingbasic helix-loop-helixbHLHtranscription factortranscriptional repressorhistone deacetylaseHDACN-CoRSin3AAMLacute myeloid leukemiaNvynervy
髓系转位基因(MTG)蛋白是转录抑制因子，在物种间高度保守。我们用原位杂交的方法研究了该基因家族的三个成员MTGR1、MTG8和MTG16在发育中的小鼠中枢神经系统中的表达。所有这些基因早在胚胎11.5天就被检测到。由于已知这些基因是在神经发生过程中由原神经基因诱导的，我们分析了MTG基因与两个原神经基因Neurog2(也称为Ngn2或Neurogenin 2)和Ascl1(也称为Mash1)的表达。虽然MTGR1通常在也表达Neurog2的区域表达，但MTG8和MTG16的表达与表达Ascl1的神经前体细胞的表达更密切相关。这些结果提示，在神经发生过程中，MTG基因的表达可能受特定的原神经基因的差异控制。
Myeloid translocation gene (MTG) proteins are transcriptional repressors that are highly conserved across species. We studied the expression of three members of this gene family, MTGR1, MTG8, and MTG16 in developing mouse central nervous system by in situ hybridization. All of these genes are detected as early as embryonic day 11.5. Because these genes are known to be induced by proneural genes during neurogenesis, we analyzed the expression of MTG genes in relation to two proneural genes, Neurog2 (also known as Ngn2 or Neurogenin 2) and Ascl1 (also known as Mash1). While MTGR1 are generally expressed in regions that also express Neurog2, MTG8 and MTG16 expression is associated more tightly with that of Ascl1-expressing neural progenitor cells. These results suggest the possibility that expression of MTG genes is differentially controlled by specific proneural genes during neurogenesis.
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