The neurotrophin receptor signaling endosome: Where trafficking meets signaling.
The neurotrophin receptor signaling endosome: Where trafficking meets signaling.
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DOI：
10.1002/dneu.22427
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发表时间：
2017-04
影响因子：
3
通讯作者：
Winckler B
中科院分区：
文献类型：
--
作者：
Barford K;Deppmann C;Winckler B
神经元是身体中最大的细胞，形成亚细胞隔间，如轴突和树突。在发育和成年期，积木必须持续长距离运输，以维持神经元的不同区域。除了构建块，信号复合体也被运输，例如，允许轴突与胞体通信。通过配体-受体复合体的信号的关键作用可能在发育的背景下得到最好的说明，在发育的背景下，它们被认为调节极化、存活、轴突生长、树突发育和突触形成。然而，知道“何时”和“多少”信号正在发生并不能提供完整的故事。信号的位置对功能结果有很大影响。因此，有复杂的和功能上重要的运输机制，以控制许多信号转导事件的精确空间和时间方面。反过来，这些信号事件中的许多都会影响贩运机制，在贩运和信号之间建立了错综复杂的联系。在这篇综述中，我们将使用神经营养素受体，特别是TrkA和TrkB，来说明贩运和信号之间联系的细胞生物学。简而言之，我们将讨论运输和信号传递如何为功能和不同的信号输出密切相关的概念，以及相同的蛋白质如何根据其定位对同一受体发挥不同的作用。
Neurons are the largest cells in the body and form subcellular compartments such as axons and dendrites. During both development and adulthood building blocks must be continually trafficked long distances to maintain the different regions of the neuron. Beyond building blocks, signaling complexes are also transported, allowing for example, axons to communicate with the soma. The critical roles of signaling via ligand–receptor complexes is perhaps best illustrated in the context of development, where they are known to regulate polarization, survival, axon outgrowth, dendrite development, and synapse formation. However, knowing ‘when’ and ‘how much’ signaling is occurring does not provide the complete story. The location of signaling has a significant impact on the functional outcomes. There are therefore complex and functionally important trafficking mechanisms in place to control the precise spatial and temporal aspects of many signal transduction events. In turn, many of these signaling events affect trafficking mechanisms, setting up an intricate connection between trafficking and signaling. In this review we will use neurotrophin receptors, specifically TrkA and TrkB, to illustrate the cell biology underlying the links between trafficking and signaling. Briefly, we will discuss the concepts of how trafficking and signaling are intimately linked for functional and diverse signaling outputs, and how the same protein can play different roles for the same receptor depending on its localization.
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