Ultrasonic vocalizations: a tool for behavioural phenotyping of mouse models of neurodevelopmental disorders.
Ultrasonic vocalizations: a tool for behavioural phenotyping of mouse models of neurodevelopmental disorders.
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DOI：
10.1016/j.neubiorev.2008.08.003
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发表时间：
2009-04
影响因子：
8.2
通讯作者：
Ricceri, Laura
中科院分区：
文献类型：
--
作者：
Scattoni, Maria Luisa;Crawley, Jacqueline;Ricceri, Laura
在新生小鼠中，超声波发声既是幼鼠母亲二人组的一种早期交流行为，也是一种厌恶情绪状态的标志。成年小鼠无论男女，在不同的实验/社会环境中都会产生复杂的超声波发声模式。所有这些发声正在成为一种越来越有价值的行为表型分析方法，在小鼠的整个生命周期中，超声模式的变化已经在几个神经发育障碍的小鼠模型中被报道。在这里，我们还表明，母性线索(母性增强范式)对发声的调制-最初在大鼠中识别和研究-可以在C57BL/6小鼠中测量，只要适当修改大鼠的实验方案，就很可能应用于小鼠的行为表型。此外，我们认为，对新生儿的叫声进行详细的定性评估，并分析成年老鼠在社会环境中的发声模式，可能会使我们更好地理解老鼠发声的交流价值。重要的是，在人类神经发育和神经精神障碍的小鼠模型的行为表型中，可以确定新生儿和成年USV改变的模式，从那些以沟通障碍为主要症状的模型开始。
In neonatal mice ultrasonic vocalizations have been studied both as an early communicative behavior of the pup-mother dyad and as a sign of an aversive affective state. Adult mice of both sexes produce complex ultrasonic vocalization patterns in different experimental/social contexts. All these vocalizations are becoming an increasingly valuable assay for behavioral phenotyping throughout the mouse life-span and alterations of the ultrasound patterns have been reported in several mouse models of neurodevelopmental disorders. Here we also show that the modulation of vocalizations by maternal cues (maternal potentiation paradigm) – originally identified and investigated in rats - can be measured in C57Bl/6 mouse pups with appropriate modifications of the rat protocol and can likely be applied to mouse behavioral phenotyping. In addition we suggest that a detailed qualitative evaluation of neonatal calls together with analysis of adult mouse vocalization patterns in both sexes in social settings, may lead to a greater understanding of the communication value of vocalizations in mice. Importantly, both neonatal and adult USV altered patterns can be determined during the behavioural phenotyping of mouse models of human neurodevelopmental and neuropsychiatric disorders, starting from those in which deficits in communication are a primary symptom.
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