Massage therapy decreases cancer-related fatigue: Results from a randomized early phase trial.
Massage therapy decreases cancer-related fatigue: Results from a randomized early phase trial.
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按摩疗法减轻了与癌症相关的疲劳：由随机的早期试验结果。
DOI：
10.1002/cncr.31064
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发表时间：
2018-02-01
期刊：
影响因子：
6.2
通讯作者：
Rapaport MH
中科院分区：
文献类型：
--
作者：
Kinkead B;Schettler PJ;Larson ER;Carroll D;Sharenko M;Nettles J;Edwards SA;Miller AH;Torres MA;Dunlop BW;Rakofsky JJ;Rapaport MH
癌症相关性疲劳（CRF）是癌症幸存者经历的一种普遍和使人衰弱的症状，但CRF的治疗选择有限。我们的研究评估了每周瑞典按摩疗法（SMT）与积极控制条件（轻触，LT）和等待列表控制（WLC）对乳腺癌幸存者持续CRF的疗效。SMT、LT和WLC的该早期随机、单盲、6周研究招募了66名年龄32-72岁的女性0-III期乳腺癌幸存者，其接受了手术加放疗和/或化疗/化学预防，伴有CRF（简明疲劳量表> 25）。主要结局是多维疲劳量表（MFI），其次是NIH PROMIS疲劳量表。57例可评价受试者的平均基线MFI评分分别为SMT 62.95、LT 55.00和WLC 60.41。SMT导致6周平均（sd）MFI总分降低-16.50（6.37）（N=20），而LT（N=20）为-8.06（6.50），WLC（N=17）增加5.88（6.48）分（治疗-时间P<0.0001）。平均基线PROMIS疲劳评分为：SMT 22.25; LT 22.05和WLC 23.24。SMT的PROMIS疲劳评分平均（sd）降低为−5.49（2.53）分，而LT为−3.24（2.57）分，WLC为−0.06（1.88）分（治疗-时间P=0.0008）。对SMT比LT更高的可信度、期望和偏好并不能解释这些结果。SMT可显著缓解CRF临床症状。这表明，6周的安全，广泛接受的手动干预会显着减少疲劳，这是癌症幸存者的一种使人衰弱的后遗症。
Cancer-related fatigue (CRF) is a prevalent and debilitating symptom experienced by cancer survivors, yet treatment options for CRF are limited. Our study evaluated the efficacy of weekly Swedish Massage Therapy (SMT) vs. an active control condition (light touch, LT) and waitlist control (WLC) on persistent CRF in breast cancer survivors. This early phase randomized, single-masked, 6-week investigation of SMT, LT and WLC enrolled 66 female Stage 0-III breast cancer survivors age 32–72 who had received surgery plus radiation and/or chemotherapy/chemoprevention with CRF (Brief Fatigue Inventory > 25). The primary outcome was the Multidimensional Fatigue Inventory (MFI), with the NIH PROMIS Fatigue scale secondary. Mean baseline MFI scores for 57 evaluable subjects were 62.95 for SMT, 55.00 for LT, and 60.41 for WLC. SMT resulted in a mean (sd) 6-week reduction in MFI total scores of −16.50 (6.37) (N=20), compared to −8.06 (6.50) for LT (N=20) and an increase of 5.88 (6.48) points for WLC (N=17) (treatment-by-time P<0.0001). Mean baseline PROMIS Fatigue scores were: SMT 22.25; LT 22.05 and WLC 23.24. Mean (sd) reduction in PROMIS Fatigue scores was −5.49 (2.53) points for SMT, compared to −3.24 (2.57) points for LT and −0.06 (1.88) points for WLC (treatment-by-time P=0.0008). Higher credibility, expectancy, and preference for SMT than for LT did not account for these results. SMT produced clinically significant relief of CRF. This suggests that 6 weeks of a safe, widely accepted manual intervention causes a significant reduction in fatigue, a debilitating sequela for cancer survivors.
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影响因子：
45.3
作者：
Berger, Ann M.;Kuhn, Brett R.;Agrawal, Sangeeta
通讯作者：
Agrawal, Sangeeta
DOI：
10.1093/jncimonographs/lgu041
发表时间：
2014-11-01
期刊：
Journal of the National Cancer Institute Monographs
影响因子：
--
作者：
Greenlee, Heather;Balneaves, Lynda G.;Tripathy, Debu
通讯作者：
Tripathy, Debu
影响因子：
3.1
作者：
Curran, SL;Beacham, AO;Andrykowski, MA
通讯作者：
Andrykowski, MA
影响因子：
2.2
作者：
Egan, Mary Y.;McEwen, Sara;Eldred, Susan
通讯作者：
Eldred, Susan
DOI：
10.1016/s0005-7916(00)00012-4
发表时间：
2000-06-01
影响因子：
1.8
作者：
Devilly, GJ;Borkovec, TD
通讯作者：
Borkovec, TD