Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.

Genetic determinants of plasma triglyceride levels in (OLETF x BN) x OLETF backcross rats.
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(OLETF x BN) x OLETF 回交大鼠血浆甘油三酯水平的遗传决定因素。

DOI：
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发表时间：
1999
期刊：
Genomics
影响因子：
4.4
通讯作者：
A. Tanigami
A. Tanigami
中科院分区：
生物学3区
文献类型：
--
作者：
S. Okuno;T. Watanabe;T. Ono;Y. Yamasaki;Y. Goto;H. Miyao;T. Asai;N. Kanemoto;K. Oga;A. Mizoguchi‐Miyakita;T. Takagi;E. Takahashi;Y. Nakamura;A. Tanigami

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尽管影响高脂血症的遗传因素尚未明确，但脂质代谢的改变与人类糖尿病密切相关。我们之前建立的OLETF品系是II型糖尿病肥胖大鼠模型，表现出高血糖以及高胰岛素血症、高血糖、胰岛素抵抗和丰富的腹部脂肪。为了确定导致 OLETF 大鼠血脂异常表型的遗传因素，我们使用 293 只雄性 (OLETF x BN) x OLETF 回交大鼠进行了全基因组扫描。我们的分析在大鼠 1 号和 8 号染色体上确定了两个与空腹甘油三酯水平相关的显着数量性状基因座 (QTL)。 1 号染色体 QTL 与 Dmo1（糖尿病，OLETF 1 型）共定位，该基因座先前已显示与脂肪水平和体重密切相关。另一个重要的 QTL 定位于 8 号染色体标记 D8Mit2，该区域是多个载脂蛋白基因聚集的区域。
Altered lipid metabolism is closely associated with diabetes in humans, although predisposing genetic factors that affect hyperlipidemia have not yet been clarified. Our previously established OLETF strain is an obese rat model of type II diabetes, exhibiting hypertriglycemia as well as hyperinsulinemia, hyperglycemia, insulin resistance, and abundant abdominal fat. To identify genetic factors responsible for dyslipidemic phenotypes in OLETF rats, we performed a whole-genome scan using 293 male (OLETF x BN) x OLETF backcross rats. Our analysis identified two significant quantitative trait loci (QTLs), on rat chromosomes 1 and 8, that are related to fasting triglyceride levels. The chromosome 1 QTL colocalized with Dmo1 (diabetes mellitus, OLETF type 1), a locus previously shown to associate strongly with both fat levels and body weight. The other significant QTL localizes to the chromosome 8 marker D8Mit2, in a region where several apo-lipoprotein genes are clustered.
Fasting hypertriglyceridemia in noninsulin-dependent diabetes mellitus is an important predictor of postprandial lipid and lipoprotein abnormalities.
DOI： 10.1210/jcem-72-4-934
发表时间： 1991-04
期刊： The Journal of clinical endocrinology and metabolism
影响因子： --
作者：
G. Lewis;N. O'Meara;P. Soltys;J. Blackman;P. Iverius;W. Pugh;G. Getz;K. Polonsky
通讯作者： G. Lewis;N. O'Meara;P. Soltys;J. Blackman;P. Iverius;W. Pugh;G. Getz;K. Polonsky
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DOI： 10.1101/gr.9.6.ap1
发表时间： 1999-05
期刊： Genome research
影响因子： 7
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通讯作者： R. Steen;A. Kwitek-Black;Christopher Glenn;J. Gullings-Handley;W. V. Etten;O. Atkinson;D. Appel;S. Twigger;Melanie Muir;Tim Mull;M. Granados;Mushira Kissebah;Kerri Russo;Robbin Crane;M. Popp;M. Peden;T. Matise;Donna M. Brown;Jian Lu;S. Kingsmore;P. Tonellato;S. Rozen;D. Slonim;Peter Young;M. Knoblauch;A. Provoost;Detlev Ganten;S. Colman;J. Rothberg;E. Lander;H. Jacob