The physiological role of drug transporters.
The physiological role of drug transporters.
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DOI：
10.1007/s13238-015-0148-2
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发表时间：
2015-05
期刊：
影响因子：
21.1
通讯作者：
Chen, Ligong
中科院分区：
文献类型：
--
作者：
Liang, Yu;Li, Siqi;Chen, Ligong
转运蛋白是人体最大的膜蛋白家族，包括溶质载体转运蛋白家族和atp结合盒转运蛋白家族。它们在外源和内源分子的吸收、分布和排泄中起着关键作用。转运蛋白在各种人体组织中广泛表达，并在药物开发和批准过程中进行常规评估。在过去的十年中，越来越多的证据表明药物转运体在正常生理和疾病中都很重要。目前，转运蛋白被用作治疗多种疾病的靶点，如糖尿病、重度抑郁症、高血压和便秘。尽管转运蛋白生物学领域稳步发展，但转运蛋白超家族中超过一半的成员对其内源性底物或生理功能知之甚少。本文综述了目前转运体研究的研究方法，总结了药物-转运体相互作用，包括药物-药物相互作用和药物-内源性底物相互作用。最后，我们还从转运蛋白的生理和病理生理作用的角度讨论了转运蛋白的治疗前景。
Transporters comprise the largest family of membrane proteins in human organism, including members of solute carrier transporter and ATP-binding cassette transporter families. They play pivotal roles in the absorption, distribution and excretion of xenobiotic and endogenous molecules. Transporters are widely expressed in various human tissues and are routinely evaluated during the process of drug development and approval. Over the past decade, increasing evidence shows that drug transporters are important in both normal physiology and disease. Currently, transporters are utilized as therapeutic targets to treat numerous diseases such as diabetes, major depression, hypertension and constipation. Despite the steady growth of the field of transporter biology, more than half of the members in transporter superfamily have little information available about their endogenous substrate(s) or physiological functions. This review outlines current research methods in transporter studies, and summarizes the drug-transporter interactions including drug-drug and drug-endogenous substrate interactions. In the end, we also discuss the therapeutic perspective of transporters based on their physiological and pathophysiological roles.
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影响因子：
30.8
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影响因子：
17.3
作者：
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通讯作者：
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DOI：
10.1073/pnas.1200853109
发表时间：
2012-07-10
影响因子：
11.1
作者：
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通讯作者：
Freedman, Matthew L.
影响因子：
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作者：
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