The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study.
The relation between past exposure to fine particulate air pollution and prevalent anxiety: observational cohort study.
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过去接触细颗粒空气污染与普遍焦虑之间的关系：观察性队列研究。
DOI：
10.1136/bmj.h1111
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发表时间：
2015-03-24
期刊：
影响因子：
--
通讯作者：
Weisskopf MG
中科院分区：
文献类型：
--
作者：
Power MC;Kioumourtzoglou MA;Hart JE;Okereke OI;Laden F;Weisskopf MG
目的了解以往较高的颗粒物空气污染暴露是否与普遍存在的高焦虑症状有关。设计观察性队列研究。设置护士健康研究。参与者71 271名妇女参加了护士健康研究，她们居住在美国各地，对至少一个感兴趣的暴露期的颗粒物暴露有有效的估计，并有焦虑症状的数据。主要结果测量有意义的高焦虑症状，定义为在2004年实施的Crown-Crisp指数的恐惧焦虑子量表中得分为6分或更高。结果7271名符合条件的女性在评估焦虑症状时年龄在57 ~ 85岁之间（平均70岁），高焦虑症状患病率为15%。通过评估焦虑症状前1个月、3个月、6个月、1年和15年对直径<2.5 μm （PM2.5）和直径2.5至10 μm （PM2.5-10）颗粒物的平均暴露量，以及评估前2年到最近主要道路的住所距离，来表征颗粒物暴露。在多个平均时期内，PM2.5暴露水平越高，出现高焦虑症状的几率就越高（例如，前一个月平均PM2.5每增加10微克/立方米的比值比为1.12,95%可信区间为1.06至1.19；前12个月平均PM2.5的比值比为1.15,1.06至1.26）。包括多个暴露窗口的模型表明，短期平均周期比长期平均周期更相关。焦虑与暴露于PM2.5-10之间没有关联。住宅靠近主要道路与焦虑症状无剂量依赖关系。结论：细颗粒物（PM2.5）暴露与高度焦虑症状相关，近期暴露可能比长期暴露更相关。研究评估减少环境PM2.5暴露是否会减少临床相关焦虑症状的人群负担是有必要的。
Objective To determine whether higher past exposure to particulate air pollution is associated with prevalent high symptoms of anxiety. Design Observational cohort study. Setting Nurses’ Health Study. Participants 71 271 women enrolled in the Nurses’ Health Study residing throughout the contiguous United States who had valid estimates on exposure to particulate matter for at least one exposure period of interest and data on anxiety symptoms. Main outcome measures Meaningfully high symptoms of anxiety, defined as a score of 6 points or greater on the phobic anxiety subscale of the Crown-Crisp index, administered in 2004. Results The 71 271 eligible women were aged between 57 and 85 years (mean 70 years) at the time of assessment of anxiety symptoms, with a prevalence of high anxiety symptoms of 15%. Exposure to particulate matter was characterized using estimated average exposure to particulate matter <2.5 μm in diameter (PM2.5) and 2.5 to 10 μm in diameter (PM2.5-10) in the one month, three months, six months, one year, and 15 years prior to assessment of anxiety symptoms, and residential distance to the nearest major road two years prior to assessment. Significantly increased odds of high anxiety symptoms were observed with higher exposure to PM2.5 for multiple averaging periods (for example, odds ratio per 10 µg/m3 increase in prior one month average PM2.5: 1.12, 95% confidence interval 1.06 to 1.19; in prior 12 month average PM2.5: 1.15, 1.06 to 1.26). Models including multiple exposure windows suggested short term averaging periods were more relevant than long term averaging periods. There was no association between anxiety and exposure to PM2.5-10. Residential proximity to major roads was not related to anxiety symptoms in a dose dependent manner. Conclusions Exposure to fine particulate matter (PM2.5) was associated with high symptoms of anxiety, with more recent exposures potentially more relevant than more distant exposures. Research evaluating whether reductions in exposure to ambient PM2.5 would reduce the population level burden of clinically relevant symptoms of anxiety is warranted.
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DOI：
10.1097/ede.0b013e31824523f0
发表时间：
2012-03
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bind MA;Baccarelli A;Zanobetti A;Tarantini L;Suh H;Vokonas P;Schwartz J
通讯作者：
Schwartz J
影响因子：
5.4
作者：
Faustini, Annunziata;Stafoggia, Massimo;Forastiere, Francesco
通讯作者：
Forastiere, Francesco
影响因子：
4.6
作者：
BRIERE, J;DOWNES, A;SPENSLEY, J
通讯作者：
SPENSLEY, J
影响因子：
10
作者：
Araujo JA;Nel AE
通讯作者：
Nel AE
影响因子：
10.4
作者：
Babisch W;Wolf K;Petz M;Heinrich J;Cyrys J;Peters A
通讯作者：
Peters A