Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B.
Distinct patterns of serum hepatitis B core-related antigen during the natural history of chronic hepatitis B.
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DOI：
10.1186/s12876-017-0703-9
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发表时间：
2017-12-04
影响因子：
2.4
通讯作者：
Feng YL
中科院分区：
文献类型：
--
作者：
Zhang ZQ;Zhang XN;Lu W;Wang YB;Weng QC;Feng YL
目前慢性B型肝炎（CH B）的临床实践需要更好地监测病毒持续存在。乙型肝炎B表面抗原（HBsAg）和核心相关抗原（HBcrAg）的定量检测有望进一步优化治疗。在这里，我们的目的是在慢性乙型肝炎的自然过程中HBcrAg的特点。444例未经治疗的CHB患者均接受了肝脏组织学检查，入选本横断面研究。他们的HBV DNA，HBsAg，HBeAg和HBcrAg滴度进行定量和分析的背景下，四个不同的临床阶段。并将HBcrAg、HBsAg与其他标志物进行相关分析。还评估了肝脏和血清抗原水平之间的关系。HBcrAg和HBsAg一样，与HBVDNA高度相关。在免疫耐受期（IT）和免疫清除期（IC），HBcrAg与HBeAg滴度呈显著的线性关系，而在HBeAg阴性肝炎（ENH）组，HBVDNA是HBcrAg的主要决定因素。肝HBcAg评分和HBcrAg水平在IT期和IC期均有显著性差异，而肝HBsAg评分和HBsAg滴度之间几乎没有显著性正相关。HBcrAg滴度具有明显的阶段特异性相关性。此外，其水平与肝内核心抗原的表达密切相关。它在监测和改进抗病毒治疗方面具有相当大的实用性。
The current clinical practice on chronic hepatitis B (CHB) requires better on-treatment monitoring of viral persistence. Quantified assays for hepatitis B surface antigen (HBsAg) and core-related antigen (HBcrAg) hold promise for further optimization of therapy. Here, we aimed to characterize HBcrAg during the natural course of CHB. Four-hundred and forty four treatment naïve CHB patients, who all underwent liver histology examination, were enrolled in this cross-sectional study. Their HBV DNA, HBsAg, HBeAg and HBcrAg titres were quantified and analyzed in the context of four distinct clinical phases. Correlation of HBcrAg and HBsAg with other markers were performed. The relationship between liver and serum antigen levels were also assessed. HBcrAg, like HBsAg, exhibited high degree of correlation with HBV DNA. However, a more significant linear relationship was found between HBcrAg and HBeAg titre in immune tolerant (IT) and immune clearance (IC) phases, while in HBeAg negative hepatitis (ENH) group, HBV DNA is a major determinant of HBcrAg. Significant difference was observed in liver HBcAg score and HBcrAg level in both IT and IC phases whereas barely significant positive correlations between liver HBsAg score and HBsAg titre was documented. HBcrAg titre exhibited distinct correlative profile in a phase-specific manner. In addition, its level is well-related to the intrahepatic expression of core antigen. It has a considerable utility in monitoring and refining antiviral therapy.
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影响因子：
25.7
作者：
Nguyen, Tin;Thompson, Alexander J. V.;Locarnini, Stephen A.
通讯作者：
Locarnini, Stephen A.
影响因子：
13.5
作者：
Thompson, Alexander J. V.;Nguyen, Tin;Locarnini, Stephen A.
通讯作者：
Locarnini, Stephen A.
影响因子：
2.5
作者：
Rokuhara, A;Tanaka, E;Kiyosawa, K
通讯作者：
Kiyosawa, K
影响因子：
14.2
作者：
van Campenhout, M. J. H.;Brouwer, W. P.;Janssen, H. L. A.
通讯作者：
Janssen, H. L. A.
影响因子：
12.7
作者：
GERKEN, G;MANNS, M;ZUMBUSCHENFELDE, KHM
通讯作者：
ZUMBUSCHENFELDE, KHM