Primary cutaneous anaplastic large-cell lymphoma--case report.

Primary cutaneous anaplastic large-cell lymphoma--case report.
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DOI:
10.1590/abd1806-4841.20131731
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发表时间:
2013-11
影响因子:
1.7
通讯作者:
Almeida WL
Almeida WL
中科院分区:
医学4区
文献类型:
--
作者:
Oliveira LS;Nobrega MP;Monteiro MG;Almeida WL

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原发性皮肤间变性大细胞淋巴瘤是CD 30+淋巴增生性皮肤病变的一部分,其特征是单个或多灶性溃疡结节,是自消退和复发性的。可发生皮外播散,尤其是局部淋巴结。组织学检查显示弥漫性、非亲表皮性浸润、免疫组织化学CD 30+、CD 4+、EMA-/+、ALK-、CD 15-和TIA 1-/+的间变性大淋巴细胞。预后良好,不依赖于淋巴浸润。放射治疗、病灶切除和/或低剂量甲氨蝶呤是治疗的选择。本研究报告的情况下,57岁的妇女提出原发性皮肤间变性大细胞淋巴瘤与多灶性病变。7年后,起搏器出现肺部受累。她表现出良好的反应与低剂量甲氨蝶呤每周处方治疗。
Primary cutaneous anaplastic large-cell lymphoma is part of the spectrum of CD30+ lymphoproliferative cutaneous processes, characterized by single or multifocal nodules that ulcerate, are autoregressive and recurrent. Extracutaneous dissemination may occur, especially to regional lymph nodes. Histology shows a diffuse, non-epidermotropic infiltrate , anaplastic large lymphoid cells of immunohistochemistry CD30+, CD4+, EMA-/+, ALK-, CD15- and TIA1-/+. Prognosis is good and does not depend on lymphatic invasion. Radiotherapy, removal of the lesion and/or low-dose methotrexate are the treatments of choice. The present study reports the case of a 57-year-old-woman presenting Primary cutaneous anaplastic large-cell lymphoma with multifocal lesions. The pacient evolved with pulmonary involvement 7 years later. She showed a good response to the treatment with low-dose methotrexate prescribed weekly.
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