Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer.
Vascular endothelial growth factor and platelet-derived endothelial cell growth factor are frequently coexpressed in highly vascularized human breast cancer.
复制标题
血管内皮生长因子和血小板源性内皮细胞生长因子经常在高度血管化的人类乳腺癌中共表达。
作者：
Masakazu Toi;Kazuo Inada;S. Hoshina;Hideo Suzuki;S. Kondo;Takeshi Tominaga;Japan
已知血管内皮生长因子（VEGF）和血小板源性内皮细胞生长因子（PD-ECGF）在体外和体内都是血管生成生长因子。在本研究中，我们采用免疫细胞化学方法研究了人乳腺癌组织中VEGF表达与PD-ECGF表达之间的关系。在 152 例原发性乳腺癌中，分别有 84 例 (55.3%) 和 71 例 (46.7%) VEGF 和 PD-ECGF 呈阳性。 84 个 VEGF 阳性肿瘤中的 53 个 (63. 1%) 具有 PD-ECGF 阳性表型，而 68 个 VEGF 阴性肿瘤中只有 18 个 (26.5%) 具有 PD-ECGF 阳性表型。 VEGF表达与PD-ECGF表达呈显着相关（P < 0.01）。作为单一因素，VEGF 表达和 PD-ECGF 表达与使用抗因子 VIII 相关抗原 mAb 进行免疫细胞化学分析评估的微血管密度增加显着相关。此外，有趣的是，在 53 个微血管计数超过 100 个/1 mm2 的肿瘤中，40 个（75.5%）同时具有 VEGF 和 PD-ECGF 阳性表型。研究发现，VEGF 和 PD-ECGF 经常在具有高微血管计数的高度血管化肿瘤中共表达。提示VEGF和PD-ECGF可能在人乳腺癌的新生血管形成中协同作用。
Vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) are known to be angiogenic growth factors in vitro and in vivo. In this study, we have investigated the relationship between VEGF expression and PD-ECGF expression in human breast cancer tissues using immunocytochemical methods. Of 152 primary breast cancers, 84 (55.3%) and 71 (46.7%) were positive for VEGF and PD-ECGF, respectively. Fifty-three (63. 1%) of 84 VEGF-positive tumors had a PD-ECGF-positive phenotype, whereas only 18 (26.5%) of 68 VEGF-negative tumors had a PD-ECGF-positive phenotype. There was a significant correlation between the VEGF expression and PD-ECGF expression (P < 0.01). As a single factor, VEGF expression and PD-ECGF expression were significantly associated with an increase in the microvessel density assessed by the immunocytochemical analysis using antifactor VIII-related antigen mAb. Interestingly, in addition, of 53 tumors with more than 100 microvessel counts/1 mm2, 40 (75.5%) had both VEGF- and PD-ECGF-positive phenotypes. It was found that VEGF and PD-ECGF were frequently coexpressed in highly vascularized tumors with high microvessel counts. It is suggested that VEGF and PD-ECGF might cooperatively function in the neovascularization of human breast cancer.
影响因子：
56.9
作者：
DEVRIES, C;ESCOBEDO, JA;WILLIAMS, LT
通讯作者：
WILLIAMS, LT
影响因子：
56.9
作者：
DAMERON, KM;VOLPERT, OV;BOUCK, N
通讯作者：
BOUCK, N