3-Dimensional quantitative detection of nanoparticle content in biological tissue samples after local cancer treatment
3-Dimensional quantitative detection of nanoparticle content in biological tissue samples after local cancer treatment
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局部癌症治疗后生物组织样品中纳米颗粒含量的三维定量检测
DOI：
10.1016/j.jmmm.2014.02.021
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发表时间：
2014
影响因子：
2.7
通讯作者：
Odenbach
中科院分区：
文献类型：
--
作者：
Alexiou;Trahms;Odenbach
X-ray computed tomography is nowadays used for a wide range of applications in medicine, science and technology. X-ray microcomputed tomography (XµCT) follows the same principles used for conventional medical CT scanners, but improves the spatial resolution to a few micrometers. We present an example of an application of X-ray microtomography, a study of 3-dimensional biodistribution, as along with the quantification of nanoparticle content in tumoral tissue after minimally invasive cancer therapy. One of these minimal invasive cancer treatments is magnetic drug targeting, where the magnetic nanoparticles are used as controllable drug carriers. The quantification is based on a calibration of the XµCT-equipment. The developed calibration procedure of the X-ray-µCT-equipment is based on a phantom system which allows the discrimination between the various gray values of the data set. These phantoms consist of a biological tissue substitute and magnetic nanoparticles. The phantoms have been studied with XµCT and have been examined magnetically. The obtained gray values and nanoparticle concentration lead to a calibration curve. This curve can be applied to tomographic data sets. Accordingly, this calibration enables a voxel-wise assignment of gray values in the digital tomographic data set to nanoparticle content. Thus, the calibration procedure enables a 3-dimensional study of nanoparticle distribution as well as concentration.
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斯特拉伦新艺术
DOI：
--
发表时间：
--
期刊：
影响因子：
--
作者：
W. C. Roentgen
通讯作者：
W. C. Roentgen
X 射线微计算机断层扫描作为研究磁性纳米颗粒生物分布的工具。
影响因子：
5.5
作者：
H. Rahn;S. Odenbach
通讯作者：
S. Odenbach
用于磁性纳米粒子生物分布定量断层扫描分析的校准模型
DOI：
--
发表时间：
2010
期刊：
影响因子：
--
作者：
H. Rahn;M. Kettering;H. Richter;I. Hilger;L. Trahms;S. Odenbach
通讯作者：
S. Odenbach
使用实验和商用 μCT 扫描仪对组织中纳米颗粒含量进行 3D 半定量
DOI：
--
发表时间：
2012
期刊：
影响因子：
--
作者：
H. Rahn;K. Bayer;S. Odenbach;S. Lyer;C. Alexiou;F. Wiekhorst;L. Trahms;M. Baumann;Julia Buckwar;M. Krause
通讯作者：
M. Krause