Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond.
Emerging Roles of Sonic Hedgehog in Adult Neurological Diseases: Neurogenesis and Beyond.
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DOI：
10.3390/ijms19082423
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发表时间：
2018-08-16
影响因子：
5.6
通讯作者：
Yang DI
中科院分区：
文献类型：
--
作者：
Chen SD;Yang JL;Hwang WC;Yang DI
Sonic hedgehog (Shh), a member of the hedgehog (Hh) family, was originally recognized as a morphogen possessing critical characters for neural development during embryogenesis. Recently, however, Shh has emerged as an important modulator in adult neural tissues through different mechanisms such as neurogenesis, anti-oxidation, anti-inflammation, and autophagy. Therefore, Shh may potentially have clinical application in neurodegenerative diseases and brain injuries. In this article, we present some examples, including ours, to show different aspects of Shh signaling and how Shh agonists or mimetics are used to alter the neuronal fates in various disease models, both in vitro and in vivo. Other potential mechanisms that are discussed include alteration of mitochondrial function and anti-aging effect; both are critical for age-related neurodegenerative diseases. A thorough understanding of the protective mechanisms elicited by Shh may provide a rationale to design innovative therapeutic regimens for various neurodegenerative diseases.
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DOI：
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期刊：
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影响因子：
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影响因子：
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影响因子：
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