Ion release from, and fluoride recharge of a composite with a fluoride-containing bioactive glass.
Ion release from, and fluoride recharge of a composite with a fluoride-containing bioactive glass.
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DOI：
10.1016/j.dental.2014.07.012
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发表时间：
2014-10
期刊：
影响因子：
5
通讯作者：
Ferracane, Jack L.
中科院分区：
文献类型：
--
作者：
Davis, Harry B.;Gwinner, Fernanda;Mitchell, John C.;Ferracane, Jack L.
能够释放钙和氟化物等离子的材料是牙本质和牙釉质再矿化所必需的，多年来一直是人们深入研究的课题。钙的来源通常是某种形式的磷酸钙，而氟化物的来源是几种金属氟化物或六氟磷酸盐中的一种。采用溶胶-凝胶法制备的含氟生物活性玻璃（BAG）作为水溶液中钙离子和氟离子的单一来源。本研究的目的是确定在复合配方中添加BAG后，是否可以作为长期释放钙和氟离子的单一来源，并确定含BAG的复合材料在暴露于5000 ppm氟化物溶液后是否可以重新充电。采用溶胶-凝胶法制备了BAG 61 （61% Si, 31% Ca, 4% P, 3% F, 1% B）和BAG 81 （81% Si, 11% Ca, 4% P, 3% F, 1% B）。所使用的复合材料由50/50 Bis-GMA/TEGDMA、0.8% EDMAB、0.4% CQ和0.05% BHT组成，再加上BAG（15%）和锶玻璃（85%）的混合物，填料总重量为72%。准备好磁盘，静置24小时，研磨，然后放入去水中。分别用原子吸收光谱法和氟离子选择电极法测定复合样品在2、22和222 h后的钙和氟释放量。然后将复合样品在5000 ppm的氟水溶液中浸泡5 min，在2、22和222 h时再次测定钙和氟的释放量。补液前，BAG 61和BAG 81复合材料在2 h后的氟离子释放量相似，在22 h后也相似。在补液前和补液后的4个时间点，BAG 81复合材料释放的氟离子明显多于补液前和补液后的4个时间点（p<0.05）。两种复合材料都通过暴露于5000 ppm氟化物进行充电，尽管BAG 81复合材料的充电次数比BAG 61复合材料多。在2 h和22 h的时间段内，BAG 61复合材料在氟化物补给之前释放了大量的钙离子。此后，两种复合材料在4个时间点钙的释放量无显著差异（p < 0.05）。这些结果表明，当添加到复合配方中时，通过溶胶-凝胶途径制成的含氟生物活性玻璃可以作为钙离子和氟离子的单一来源，并且复合材料可以很容易地重新充电氟化物。
Materials that are capable of releasing ions such as calcium and fluoride, that are necessary for remineralization of dentin and enamel, have been the topic of intensive research for many years. The source of calcium has most often been some form of calcium phosphate, and that for fluoride has been one of several metal fluoride or hexafluorophosphate salts. Fluoride-containing bioactive glass (BAG) prepared by the sol-gel method acts as a single source of both calcium and fluoride ions in aqueous solutions. The objective of this investigation was to determine if BAG, when added to a composite formulation, can be used as a single source for calcium and fluoride ion release over an extended time period, and to determine if the BAG-containing composite can be recharged upon exposure to a solution of 5,000 ppm fluoride. BAG 61 (61% Si; 31% Ca; 4% P; 3% F; 1% B) and BAG 81 (81% Si; 11% Ca; 4% P; 3% F; 1% B) were synthesized by the sol gel method. The composite used was composed of 50/50 Bis-GMA/TEGDMA, 0.8% EDMAB, 0.4% CQ, and 0.05% BHT, combined with a mixture of BAG (15%) and strontium glass (85%) to a total filler load of 72% by weight. Disks were prepared, allowed to age for 24 h, abraded, then placed into DI water. Calcium and fluoride release was measured by atomic absorption spectroscopy and fluoride ion selective electrode methods, respectively, after 2, 22, and 222 h. The composite samples were then soaked for 5 min in an aqueous 5,000 ppm fluoride solution, after which calcium and fluoride release was again measured at 2, 22, and 222 h time points. Prior to fluoride recharge, release of fluoride ions was similar for the BAG 61 and BAG 81 composites after 2 h, and also similar after 22 h. At the four subsequent time points, one prior to, and three following fluoride recharge, the BAG 81 composite released significantly more fluoride ions (p<0.05). Both composites were recharged by exposure to 5,000 ppm fluoride, although the BAG 81 composite was recharged more than the BAG 61 composite. The BAG 61 composite released substantially more calcium ions prior to fluoride recharge during each of the 2 and 22 h time periods. Thereafter, the release of calcium at the four subsequent time points was not significantly different (p>0.05) for the two composites. These results show that, when added to a composite formulation, fluoride-containing bioactive glass made by the sol-gel route can function as a single source for both calcium and fluoride ions, and that the composite can be readily recharged with fluoride.
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影响因子：
3
作者：
DUGGAL, MS;CHAWLA, HS;CURZON, MEJ
通讯作者：
CURZON, MEJ
影响因子：
5
作者：
Chan, WLD;Yang, LF;Rizkalla, AS
通讯作者：
Rizkalla, AS
影响因子：
2.7
作者：
Caldeira, Erika Machado;Osorio, Amanda;Nojima, Matilde da Cunha Goncalves
通讯作者：
Nojima, Matilde da Cunha Goncalves
影响因子：
7.6
作者：
DUCKWORTH, RM;MORGAN, SN;MURRAY, AM
通讯作者：
MURRAY, AM
影响因子：
--
作者：
Brauer, Delia S.;Karpukhina, Natalia;Hill, Robert G.
通讯作者：
Hill, Robert G.