A prospective study of childhood social hardships and age at menarche.
A prospective study of childhood social hardships and age at menarche.
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DOI：
10.1016/j.annepidem.2012.08.005
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发表时间：
2012-10
影响因子：
5.6
通讯作者：
Harville, Emily W.
中科院分区：
文献类型：
--
作者：
Boynton-Jarrett, Renee;Harville, Emily W.
在一项前瞻性队列研究中，确定类型、时间和累积的儿童期困难对初潮年龄的作用。对全国儿童发展研究队列（1958 - 2003年）的4 524名女性参与者进行纵向分析。六种类型的儿童时期的困难，确定了一个因素分析方法：经济，家庭功能障碍，照顾者对教育的兴趣低，缺乏支持性的教育，忽视的环境，和家庭结构的破坏。童年时期父亲的缺席/参与度低是一种先天的困难。还对儿童期虐待的回顾性报告与初潮年龄的关系进行了探讨。广义logit回归分析探讨了类型、时间和累积困难对初潮年龄（≤11岁、12-13岁、≥14岁）的影响。累积的儿童期困难与后期月经初潮风险的分级增加相关，在有2、3和≥4次不良事件的受试者中，校正OR [AOR]分别为1.37（95%CI：1.10，1.70）、1.50（95%CI：1.18，1.91）和1.58（95%CI：1.29，1.92）。早期生活中有2次以上的困难与月经初潮晚相关性最强（AOR=2.32，95%CI：1.12，4.80）。性虐待与月经初潮提前密切相关（AOR=2.60，95%CI：1.40，4.81）。童年时期的艰苦生活增加了以后月经初潮的风险。虐待儿童与初潮的早期和晚期都有关联，尽管这种关联因虐待类型而异。暴露的关键时期，类型和长期的困难表现出不同程度的影响初潮年龄。
To determine the role of type, timing, and cumulative childhood hardships on age at menarche in a prospective cohort study. Longitudinal analysis of 4,524 female participants of the National Child Development Study cohort (1958 – 2003). Six types of childhood hardships were identified with a factor analysis methodology: financial, family dysfunction, caregiver low interest in education, lack of supportive caregiving, neglectful environment, and family structure disruption. Paternal absence/low involvement in childhood was an a priori hardship. Retrospective reports of abuse in childhood were explored in relation to age at menarche, also. Generalized logit regression analyses explored the impact of type, timing, and cumulative hardships on age at menarche (≤11, 12–13, ≥14 years). Cumulative childhood hardships were associated with a graded increase in risk for later menarche with adjusted OR [AOR] of 1.37 (95%CI: 1.10, 1.70), 1.50 (95%CI: 1.18, 1.91), and 1.58 (95%CI: 1.29, 1.92) among those with 2, 3, and ≥4 adversities, respectively. More than 2 hardships in early life had the strongest association with late menarche (AOR=2.32, 95%CI: 1.12, 4.80). Sexual abuse was most strongly associated with early menarche (AOR=2.60, 95%CI: 1.40, 4.81). Cumulative childhood hardships increased risk for later age at menarche. Child abuse was associated with both early and late menarche, although associations varied by type of abuse. Critical period of exposure, type, and chronicity of hardships demonstrate varying degrees of influence on age at menarche.
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影响因子：
1.7
作者：
do Lago, MJ;Faerstein, E;Werneck, GL
通讯作者：
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影响因子：
5
作者：
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影响因子：
4.9
作者：
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影响因子：
5.1
作者：
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通讯作者：
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影响因子：
8
作者：
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通讯作者：
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