Computer-based assessment of ventricular mechanical synchrony from magnetic resonance imaging
Computer-based assessment of ventricular mechanical synchrony from magnetic resonance imaging
复制标题
基于计算机的磁共振成像心室机械同步性评估
DOI：
--
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
L. Zhong
中科院分区：
文献类型：
--
作者：
Xiaodan Zhao;S. Leng;R. Tan;L. Zhong
心脏再同步化治疗（CRT）已经彻底改变了相当一部分晚期心力衰竭（HF）患者的护理。从目前的指南（NYHA III或IV型心力衰竭，左心室射血分数≤35%，心电图QRS持续时间≥120 ms）来看，CRT改善了约70%的治疗患者的临床状况。理想情况下，准确预测反应可能性的能力将提高治疗质量。本研究旨在开发一种通过磁共振成像（MRI）自动评估左心室机械同步的方法，磁共振成像被认为是评估心室结构和功能的金标准。前瞻性招募了26名健康志愿者（年龄从24岁到73岁不等），并进行了标准的MRI扫描。处理MRI图像（如2室、3室和4室视图），并自动跟踪心周期期间房室交界处（AVJ）的运动。收缩期心肌速度Sm1、Sm2；二尖瓣形成前期和后期的Em和Am分别得到。测定这些测量（如TSm1、TSm2、TEm和TAm）的时间，评估心室同步指数TSm1- sd -6、TSm2- sd -6、TEm- sd -6和TAm- sd -6（6个AVJ点的TSm1、TSm2、TEm和TAm的标准差）并与年龄相关。每个数据集的计算时间大约为5分钟。单因素方差分析发现，6个路段在到达峰值速度的时间上没有显著差异。其次，线性回归分析发现，TSm2-SD-6和TAm-SD-6与年龄无显著相关，TSm1-SD-6和TEm-SD-6与年龄呈正相关。在这项前瞻性研究中，非侵入性心室同步性来源于通常获得的MRI图像，提供了一种新的方法，可以评估心力衰竭的心室机械非同步性。
Cardiac resynchronization therapy (CRT) has revolutionized the care of a substantial portion of patients with advanced heart failure (HF). From current guideline (NYHA III or IV heart failure, left ventricular ejection fraction ≤35% and ECG QRS duration ≥ 120 ms), CRT improves clinical status in about 70% of those treated. Ideally, the ability to accurately predict likelihood of response will enhance the quality of treatment. This study aims to develop an automated method to assess left ventricular mechanical synchrony from magnetic resonance imaging (MRI), which has been considered as gold standard cardiac imaging for ventricular structure and function assessment. 26 healthy volunteers (age ranges from 24 years to 73 years) were prospectively recruited and underwent standard MRI scans. MRI images (e.g. 2-chamber, 3-chamber and 4-chamber views) were processed and atrioventricular junction (AVJ) motions were auto-tracked during cardiac cycle. The myocardial velocities Sm1 and Sm2 at systolic phase; Em and Am at early and late mitral filing phase, were derived respectively. The time to these measures (e.g., TSm1, TSm2, TEm and TAm) were determined and ventricular synchrony indices TSm1-SD-6, TSm2-SD-6, TEm-SD-6 and TAm-SD-6 (standard deviations of TSm1, TSm2, TEm and TAm for 6 AVJ points) were assessed and correlated with age. The computational time per dataset is approximately 5 minutes. One-way ANOVA analysis found that there were no significant differences in time to peak velocities in 6 segments. Second, linear regression analysis found that there were no significant correlation between TSm2-SD-6 and TAm-SD-6 with age, and fair positive correlation between TSm1-SD-6 and TEm-SD-6 with age. In this prospective study, noninvasive ventricular synchrony derived from typically acquired MRI images offers a novel method that may enable ventricular mechanical dyssynchrony assessment in heart failure.
DOI：
10.1152/ajpheart.00679.2011
发表时间：
2012-03-01
影响因子：
4.8
作者：
Zhong, Liang;Gobeawan, Like;Kassab, Ghassan
通讯作者：
Kassab, Ghassan
影响因子：
3.3
作者：
Lee, Lik Chuan;Wenk, Jonathan F.;Guccione, Julius M.
通讯作者：
Guccione, Julius M.