Comparison of [(18)F]DCFPyL and [ (68)Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer.
Comparison of [(18)F]DCFPyL and [ (68)Ga]Ga-PSMA-HBED-CC for PSMA-PET Imaging in Patients with Relapsed Prostate Cancer.
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DOI：
10.1007/s11307-015-0866-0
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发表时间：
2015-08
影响因子：
3.1
通讯作者：
Neumaier B
中科院分区：
文献类型：
--
作者：
Dietlein M;Kobe C;Kuhnert G;Stockter S;Fischer T;Schomäcker K;Schmidt M;Dietlein F;Zlatopolskiy BD;Krapf P;Richarz R;Neubauer S;Drzezga A;Neumaier B
用于成像前列腺特异性膜抗原（PSMA）表达的镓-68（Ga-68）标记的示踪剂（例如[68 Ga]Ga-PSMA-HBED-CC）已经证明了用于检测复发性前列腺癌的高潜力。然而，与Ga-68相比，用氟-18（F-18）标记将在可用性、生产量和图像分辨率方面提供优势。[18F]DCFPyL是最近推出的用于PSMA正电子发射断层扫描（PET）成像的有前途的F-18标记候选物。在本研究中，我们旨在比较[68 Ga]Ga-PSMA-HBED-CC和[18 F]DCFPyL在生化复发性前列腺癌中的临床应用。在14例选定的前列腺癌PSA复发患者中，除[68 Ga]Ga-PSMA-HBED-CC PET/CT外，还进行了[18 F]DCFPyL PET/X射线计算机断层扫描（CT）。在检测到的PSMA阳性病变数量、标准化摄取值（SUV）最大值和病变与背景比值方面，对两种示踪剂获得的结果进行了系统比较。所有通过[68 Ga]Ga-PSMA-HBED-CC鉴定的可疑病变也用[18 F]DCFPyL检测。在3例患者中，使用[18 F]DCFPyL PET/CT观察到其他病变。与[68 Ga]Ga-PSMA-HBED-CC相比，一致[18 F]DCFPyL PSMA阳性病变中的平均SUVmax显著更高（14.5 vs. 12.2，p = 0.028，n = 15）。使用肾、脾或腮腺作为参考器官，[18 F]DCFPyL的平均肿瘤背景比（n = 15）显著高于[68 Ga]Ga-PSMA-HBED-CC（p = 0.006，p = 0.002，p = 0.008），但使用肝脏（p = 0.167）或纵隔（p = 0.363）作为参考器官时，未发现显著差异。[18F]DCFPyL PET/CT提供了高图像质量，并以出色的灵敏度可视化小前列腺病变。[18 F]DCFPyL代表了[68 Ga]Ga-PSMA-HBED-CC在复发性前列腺癌中用于PSMA-PET/CT成像的非常有前途的替代方案。
Gallium-68 (Ga-68)-labeled tracers for imaging expression of the prostate-specific membrane antigen (PSMA) such as the [68Ga]Ga-PSMA-HBED-CC have already demonstrated high potential for the detection of recurrent prostate cancer. However, compared to Ga-68, a labeling with fluorine-18 (F-18) would offer advantages with respect to availability, production amount, and image resolution. [18F]DCFPyL is a promising F-18-labeled candidate for PSMA-positron emission tomography (PET) imaging that has been recently introduced. In the current study, we aimed to compare [68Ga]Ga-PSMA-HBED-CC and [18F]DCFPyL for clinical use in biochemically relapsed prostate cancer. In 14 selected patients with PSA relapse of prostate cancer, [18F]DCFPyL PET/X-ray computed tomography (CT) was performed in addition to [68Ga]Ga-PSMA-HBED-CC PET/CT. A systematic comparison was carried out between results obtained with both tracers with regard to the number of detected PSMA-positive lesions, the standardized uptake value (SUV)max and the lesion to background ratios. All suspicious lesions identified by [68Ga]Ga-PSMA-HBED-CC were also detected with [18F]DCFPyL. In three patients, additional lesions were observed using [18F]DCFPyL PET/CT. The mean SUVmax in the concordant [18F]DCFPyL PSMA-positive lesions was significantly higher as compared to [68Ga]Ga-PSMA-HBED-CC (14.5 vs. 12.2, p = 0.028, n = 15). The mean tumor to background ratios (n = 15) were significantly higher for [18F]DCFPyL compared to [68Ga]Ga-PSMA-HBED-CC using kidney, spleen, or parotid as reference organs (p = 0.006, p = 0.002, p = 0.008), but no significant differences were found using the liver (p = 0.167) or the mediastinum (p = 0.363) as reference organs. [18F]DCFPyL PET/CT provided a high image quality and visualized small prostate lesions with excellent sensitivity. [18F]DCFPyL represents a highly promising alternative to [68Ga]Ga-PSMA-HBED-CC for PSMA-PET/CT imaging in relapsed prostate cancer.
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DOI：
10.1158/1078-0432.ccr-11-1357
发表时间：
2011-12-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Chen Y;Pullambhatla M;Foss CA;Byun Y;Nimmagadda S;Senthamizhchelvan S;Sgouros G;Mease RC;Pomper MG
通讯作者：
Pomper MG
[68Ga]Ga-PSMA-HBED-CC 的新临床前和放射性药物方面：一种用于前列腺癌成像的新 PET 示踪剂。
DOI：
10.3390/ph7070779
发表时间：
2014-06-30
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Eder M;Neels O;Müller M;Bauder-Wüst U;Remde Y;Schäfer M;Hennrich U;Eisenhut M;Afshar-Oromieh A;Haberkorn U;Kopka K
通讯作者：
Kopka K
DOI：
10.1007/s00259-014-2713-y
发表时间：
2014-07
影响因子：
9.1
作者：
Zechmann, Christian M.;Afshar-Oromieh, Ali;Armor, Tom;Stubbs, James B.;Mier, Walter;Hadaschik, Boris;Joyal, John;Kopka, Klaus;Debus, Juergen;Babich, John W.;Haberkorn, Uwe
通讯作者：
Haberkorn, Uwe
影响因子：
3.3
作者：
Haffner, Michael C.;Kronberger, Irmgard E.;Bander, Neil H.
通讯作者：
Bander, Neil H.
DOI：
10.1007/s00259-014-2915-3
发表时间：
2015-02-01
影响因子：
9.1
作者：
Krohn, Thomas;Verburg, Frederik A.;Behrendt, Florian F.
通讯作者：
Behrendt, Florian F.