Expression of the repulsive guidance molecule RGM and its receptor neogenin after spinal cord injury in sea lamprey.
Expression of the repulsive guidance molecule RGM and its receptor neogenin after spinal cord injury in sea lamprey.
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DOI：
10.1016/j.expneurol.2009.02.011
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发表时间：
2009-06
影响因子：
5.3
通讯作者：
Selzer, Michael E.
中科院分区：
文献类型：
--
作者：
Shifman, Michael I.;Yumul, Rae Eden;Laramore, Cindy;Selzer, Michael E.
The sea lamprey recovers normal-appearing locomotion after spinal cord transection and its spinal axons regenerate selectively in their correct paths. However, among identified reticulospinal neurons some are consistently bad regenerators and only about 50% of severed reticulospinal axons regenerate through the site of injury. We previously suggested that selective chemorepulsion might explain why some neurons are bad regenerators and others not. To explore the role of additional chemorepulsive axonal guidance molecules during regeneration, we examined the expression of the repulsive guidance molecule (RGM) and its receptor neogenin by in situ hybridization and quantitative PCR. RGM mRNA was expressed in the spinal cord, primarily in neurons of the lateral gray matter and in dorsal cells. Following spinal cord transection, RGM message was downregulated in neurons close (within 10 mm) to the transection at 2 and 4 weeks, although it was upregulated in reactive microglia at 2 weeks post-transection. Neogenin mRNA expression was unchanged in the brainstem after spinal cord transection, and among the identified reticulospinal neurons, was detected only in “bad regenerators, Neurons that are known to regenerate well never expressed neogenin. The downregulation of RGM expression in neurons near the transection may increase the probability that regenerating axons will regenerate through the site of injury and entered caudal spinal cord.
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影响因子：
2.5
作者：
LURIE, DI;SELZER, ME
通讯作者：
SELZER, ME
影响因子：
3.3
作者：
LAWSON, LJ;PERRY, VH;GORDON, S
通讯作者：
GORDON, S
影响因子：
64.8
作者：
Pancer, Z;Amemiya, CT;Cooper, MD
通讯作者：
Cooper, MD
影响因子：
16.2
作者：
MCKERRACHER, L;DAVID, S;BRAUN, PE
通讯作者：
BRAUN, PE
RGMA抑制可促进脊髓损伤后的轴突生长和恢复。
DOI：
10.1083/jcb.200508143
发表时间：
2006-04-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Hata K;Fujitani M;Yasuda Y;Doya H;Saito T;Yamagishi S;Mueller BK;Yamashita T
通讯作者：
Yamashita T