RGMa inhibition promotes axonal growth and recovery after spinal cord injury.
RGMa inhibition promotes axonal growth and recovery after spinal cord injury.
复制标题
RGMA抑制可促进脊髓损伤后的轴突生长和恢复。
DOI：
10.1083/jcb.200508143
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发表时间：
2006-04-10
期刊：
影响因子：
--
通讯作者：
Yamashita T
中科院分区：
文献类型：
--
作者：
Hata K;Fujitani M;Yasuda Y;Doya H;Saito T;Yamagishi S;Mueller BK;Yamashita T
排斥导向分子（RGM）是一种参与轴突导向和神经管闭合的蛋白质。我们报告RGMa作为成年中枢神经系统（CNS）中轴突再生的有效抑制剂。RGMa通过依赖于RhoA-Rho激酶途径的活化的机制抑制哺乳动物CNS神经突生长。在成年大鼠脊髓的少突胶质细胞、有髓纤维和神经元中观察到RGMa表达，并且在脊髓损伤后在损伤部位周围诱导RGMa表达。我们开发了在体外有效阻断RGMa作用的RGMa抗体。对胸脊髓半切大鼠鞘内给予抗体可导致皮质脊髓束的显著轴突生长并改善功能恢复。因此，RGMa在CNS损伤后限制轴突再生中起重要作用，并且RGMa抗体在以CNS再生失败为特征的临床病症中提供了可能的治疗剂。
Repulsive guidance molecule (RGM) is a protein implicated in both axonal guidance and neural tube closure. We report RGMa as a potent inhibitor of axon regeneration in the adult central nervous system (CNS). RGMa inhibits mammalian CNS neurite outgrowth by a mechanism dependent on the activation of the RhoA–Rho kinase pathway. RGMa expression is observed in oligodendrocytes, myelinated fibers, and neurons of the adult rat spinal cord and is induced around the injury site after spinal cord injury. We developed an antibody to RGMa that efficiently blocks the effect of RGMa in vitro. Intrathecal administration of the antibody to rats with thoracic spinal cord hemisection results in significant axonal growth of the corticospinal tract and improves functional recovery. Thus, RGMa plays an important role in limiting axonal regeneration after CNS injury and the RGMa antibody offers a possible therapeutic agent in clinical conditions characterized by a failure of CNS regeneration.
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影响因子：
16.2
作者：
MCKERRACHER, L;DAVID, S;BRAUN, PE
通讯作者：
BRAUN, PE
影响因子：
4.2
作者：
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作者：
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影响因子：
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作者：
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影响因子：
11.4
作者：
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通讯作者：
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