Heterogeneity of the tumor vasculature.
Heterogeneity of the tumor vasculature.
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DOI：
10.1055/s-0030-1253454
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发表时间：
2010-04
影响因子：
5.7
通讯作者：
Dvorak HF
中科院分区：
文献类型：
--
作者：
Nagy JA;Chang SH;Shih SC;Dvorak AM;Dvorak HF
供应肿瘤的血管是显著异质的，并且在组织、结构和功能方面不同于它们的正常对应物。已经确定了六种明显不同的肿瘤血管类型，并且已经了解了它们形成的步骤和机制。六种血管类型中的四种（母血管、毛细血管、肾小球样微血管增生和血管畸形）通过血管生成从预先存在的正常微静脉和毛细血管发展而来。剩下的两种血管类型（供血动脉和引流静脉）是从动静脉发生发展而来的，动静脉发生是一个平行的、知之甚少的过程，涉及预先存在的动脉和静脉的重塑。所有这六种肿瘤血管类型可以通过表达血管内皮生长因子（VEGF）-A164的腺病毒载体在正常小鼠组织中依次诱导形成。目前针对VEGF-A或其受体的抗血管生成癌症疗法对癌症患者的益处有限，这可能是因为它们仅靶向需要外源性VEGF-A维持的肿瘤血管亚群的内皮细胞。未来工作的一个目标是确定肿瘤血管内皮细胞上的治疗靶点，这些细胞已经失去了这一要求。
The blood vessels supplying tumors are strikingly heterogeneous and differ from their normal counterparts with respect to organization, structure, and function. Six distinctly different tumor vessel types have been identified, and much has been learned about the steps and mechanisms by which they form. Four of the six vessel types (mother vessels, capillaries, glomeruloid microvascular proliferations, and vascular malformations) develop from preexisting normal venules and capillaries by angiogenesis. The two remaining vessel types (feeder arteries and draining veins) develop from arterio-venogenesis, a parallel, poorly understood process that involves the remodeling of preexisting arteries and veins. All six of these tumor vessel types can be induced to form sequentially in normal mouse tissues by an adenoviral vector expressing vascular endothelial growth factor (VEGF)-A164. Current antiangiogenic cancer therapies directed at VEGF-A or its receptors have been of only limited benefit to cancer patients, perhaps because they target only the endothelial cells of the tumor blood vessel subset that requires exogenous VEGF-A for maintenance. A goal of future work is to identify therapeutic targets on tumor blood vessel endothelial cells that have lost this requirement.
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影响因子：
3.6
作者：
Hess, AR;Seftor, EA;Hendrix, MJC
通讯作者：
Hendrix, MJC
影响因子：
8.8
作者：
Goffin, JR;Straume, O;Foulkes, WD
通讯作者：
Foulkes, WD
影响因子：
3.1
作者：
Feng, D;Nagy, JA;Dvorak, HF
通讯作者：
Dvorak, HF
影响因子：
9.8
作者：
Chang HY;Sneddon JB;Alizadeh AA;Sood R;West RB;Montgomery K;Chi JT;van de Rijn M;Botstein D;Brown PO
通讯作者：
Brown PO
DOI：
10.1093/jnci/87.16.1237
发表时间：
1995-08-16
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
GUIDI, AJ;ABUJAWDEH, G;BROWN, LF
通讯作者：
BROWN, LF