The crucial impact of lysosomes in aging and longevity.
The crucial impact of lysosomes in aging and longevity.
复制标题
溶酶体对衰老和寿命的关键影响。
DOI：
10.1016/j.arr.2016.04.009
复制
发表时间：
2016-12
影响因子：
13.1
通讯作者：
Ruckenstuhl, Christoph
中科院分区：
文献类型：
--
作者：
Carmona-Gutierrez, Didac;Hughes, Adam L.;Madeo, Frank;Ruckenstuhl, Christoph
Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora of cellular processes, including responses to nutrient availability and composition, stress resistance, programmed cell death, plasma membrane repair, development, and cell differentiation. In line with this pleiotropic importance for cellular and organismal life and death, lysosomal dysfunction is associated with many age-related pathologies like Parkinson’s and Alzheimer’s disease, as well as with a decline in lifespan. Conversely, targeting lysosomal functional capacity is emerging as a means to promote longevity. Here, we analyze the current knowledge on the prominent influence of lysosomes on aging-related processes, such as their executory and regulatory roles during general and selective macroautophagy, or their storage capacity for amino acids and ions. In addition, we review and discuss the roles of lysosomes as active players in the mechanisms underlying known lifespan-extending interventions like, for example, spermidine or rapamycin administration. In conclusion, this review aims at critically examining the nature and pliability of the different layers, in which lysosomes are involved as a control hub for aging and longevity.
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影响因子：
4.8
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通讯作者：
Kane, Patricia M.
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