Micelle-in-Liposomes for Sustained Delivery of Anticancer Agents That Promote Potent TRAIL-Induced Cancer Cell Apoptosis.
Micelle-in-Liposomes for Sustained Delivery of Anticancer Agents That Promote Potent TRAIL-Induced Cancer Cell Apoptosis.
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DOI：
10.3390/molecules26010157
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发表时间：
2020-12-31
期刊：
影响因子：
--
通讯作者：
King MR
中科院分区：
文献类型：
--
作者：
Zhang Z;Patel SB;King MR
肿瘤坏死因子相关凋亡诱导配体（tumor necrosis factor related apoptosis inducing ligand，TRAIL）能诱导肿瘤细胞特异性凋亡，作为一种有前途的肿瘤治疗药物，已引起人们的极大兴趣。然而，TRAIL的发展受到阻碍，部分原因是大多数人类癌细胞对TRAIL具有抗性。一些小分子，包括天然化合物，如piperlongumine（PL）已被报道，敏感癌细胞的TRAIL。我们制备了一种新型纳米材料--脂质体中的胶束（MIL），用于增溶和递送PL。负载PL的MIL用于使癌细胞对TRAIL敏感。如通过cryo-TEM观察到的，胶束成功地装载在脂质体的水性核心内。MIL使PL的水溶性增加约20倍。实现了在生理相关缓冲液中从MIL中持续释放PL超过7天，表明脂质体防止了药物从MIL中的胶束中过早释放。还证明了PL MIL与脂质体TRAIL结合在癌细胞中的有效协同凋亡作用。MIL为疏水性抗癌剂提供了新的制剂和递送载体，其可以单独使用或与TRAIL组合使用以促进癌细胞死亡。
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces cancer cell-specific apoptosis and has garnered intense interest as a promising agent for cancer treatment. However, the development of TRAIL has been hampered in part because most human cancer cells are resistant to TRAIL. A few small molecules including natural compounds such as piperlongumine (PL) have been reported to sensitize cancer cells to TRAIL. We prepared a novel type of nanomaterial, micelle-in-liposomes (MILs) for solubilization and delivery of PL. PL-loaded MILs were used to sensitize cancer cells to TRAIL. As visualized by cryo-TEM, micelles were successfully loaded inside the aqueous core of liposomes. The MILs increased the water solubility of PL by ~20 fold. A sustained PL release from MILs in physiologically relevant buffer over 7 days was achieved, indicating that the liposomes prevented premature drug release from the micelles in the MILs. Also demonstrated is a potent synergistic apoptotic effect in cancer cells by PL MILs in conjunction with liposomal TRAIL. MILs provide a new formulation and delivery vehicle for hydrophobic anticancer agents, which can be used alone or in combination with TRAIL to promote cancer cell death.
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影响因子：
4.7
作者：
通讯作者：
--
影响因子：
3.7
作者：
Oerlemans C;Bult W;Bos M;Storm G;Nijsen JF;Hennink WE
通讯作者：
Hennink WE
影响因子：
5.5
作者：
Lu J;Owen SC;Shoichet MS
通讯作者：
Shoichet MS
DOI：
10.1081/bio-120028669
发表时间：
2004-01-01
期刊：
ARTIFICIAL CELLS BLOOD SUBSTITUTES AND BIOTECHNOLOGY
影响因子：
--
作者：
Chaize, B;Colletier, JP;Fournier, D
通讯作者：
Fournier, D
影响因子：
3.8
作者：
Ortiz-Otero, Nerymar;Marshall, Jocelyn R.;King, Michael R.
通讯作者：
King, Michael R.