Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells.
Long Non-coding RNAs and MicroRNAs Interplay in Osteogenic Differentiation of Mesenchymal Stem Cells.
复制标题
DOI：
10.3389/fcell.2021.646032
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Martini F
中科院分区：
文献类型：
--
作者：
Lanzillotti C;De Mattei M;Mazziotta C;Taraballi F;Rotondo JC;Tognon M;Martini F
长链非编码RNA（lncRNA）作为许多组织中基因表达的表观遗传调节因子已受到极大关注。越来越多的证据表明，lncRNA和microRNA（miRNAs）在骨生成中起着关键作用。虽然miRNA的作用机制主要依赖于miRNA-mRNA相互作用，导致表达抑制，但lncRNA通过不同的活性影响mRNA功能，包括与miRNA的相互作用。RNA测序技术的最新进展提高了对lncRNA和miRNA相互作用调节的分子途径的认识。本文综述了lncRNA和miRNA作为成骨分化关键调节因子的最新知识。具体而言，我们在本文中描述了最近发现的lncRNA-miRNA串扰在成骨分化的间充质干细胞（MSC）来源于骨髓（BM），以及从不同的其他解剖区域。深入了解成骨分化过程中miRNA和lncRNA之间的联系将有力地提高对骨生长和发育分子机制的认识，最终导致发现成骨疾病和骨疾病的创新诊断和治疗工具。
Long non-coding RNAs (lncRNAs) have gained great attention as epigenetic regulators of gene expression in many tissues. Increasing evidence indicates that lncRNAs, together with microRNAs (miRNAs), play a pivotal role in osteogenesis. While miRNA action mechanism relies mainly on miRNA-mRNA interaction, resulting in suppressed expression, lncRNAs affect mRNA functionality through different activities, including interaction with miRNAs. Recent advances in RNA sequencing technology have improved knowledge into the molecular pathways regulated by the interaction of lncRNAs and miRNAs. This review reports on the recent knowledge of lncRNAs and miRNAs roles as key regulators of osteogenic differentiation. Specifically, we described herein the recent discoveries on lncRNA-miRNA crosstalk during the osteogenic differentiation of mesenchymal stem cells (MSCs) derived from bone marrow (BM), as well as from different other anatomical regions. The deep understanding of the connection between miRNAs and lncRNAs during the osteogenic differentiation will strongly improve knowledge into the molecular mechanisms of bone growth and development, ultimately leading to discover innovative diagnostic and therapeutic tools for osteogenic disorders and bone diseases.
登录
查看更多内容
羊水间充质干细胞的分离、培养和鉴定
影响因子：
2.6
作者：
Fei, Xuetao;Jiang, Shan;Ruiz, George
通讯作者：
Ruiz, George
影响因子：
3.7
作者：
Gallo A;Tandon M;Alevizos I;Illei GG
通讯作者：
Illei GG
影响因子：
5.6
作者：
Da Sacco L;Masotti A
通讯作者：
Masotti A
影响因子：
4
作者：
Corral-Vazquez, Celia;Blanco, Joan;Anton, Ester
通讯作者：
Anton, Ester
影响因子：
4.5
作者：
Draper JE;Sroczynska P;Tsoulaki O;Leong HS;Fadlullah MZ;Miller C;Kouskoff V;Lacaud G
通讯作者：
Lacaud G