Neonatal neurobehavior in infants with autism spectrum disorder.
Neonatal neurobehavior in infants with autism spectrum disorder.
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DOI：
10.1111/dmcn.15096
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发表时间：
2022-05
影响因子：
3.8
通讯作者：
Klaiman, Cheryl
中科院分区：
文献类型：
--
作者：
Bradshaw, Jessica;Shi, Dexin;Hendrix, Cassandra L.;Saulnier, Celine;Klaiman, Cheryl
研究后来被诊断患有自闭症谱系障碍 (ASD) 的新生儿的神经行为成熟情况。在一项前瞻性纵向设计中，每月对 ASD 家族可能性升高和降低的 1 至 3 个月大的婴儿进行新生儿神经行为检查 (n=60)。 2 岁时，对婴儿进行了临床最佳估计评估，结果显示 18 名婴儿患有自闭症谱系障碍 (ASD)，36 名婴儿发育正常。对方差模型进行重复测量分析，以检查年龄、诊断组及其相互作用的影响。被诊断患有 ASD 的婴儿的神经行为成熟度在很大程度上与 1 至 3 个月内正常发育的婴儿相当，但注意力的发展除外。患有 ASD 的婴儿从 2 至 3 个月开始，以物体为中心的注意力就显着减弱，并且可以预测 2 年后的社交沟通技能。这是第一项前瞻性研究自闭症谱系障碍家族可能性较高的婴儿的新生儿神经行为的研究，这些婴儿后来被诊断出来。尽管新生儿期的神经和行为成熟相对完整，但对物体的注意力成为自闭症谱系障碍的一个关键早期指标。这表明出生后头 3 个月内存在复杂的注意力脆弱性，这可能与社交沟通挑战和自闭症谱系障碍的出现的连锁后遗症有关。
To investigate neurobehavioral maturation for neonates who are later diagnosed with autism spectrum disorder (ASD). In a prospective longitudinal design, neonatal neurobehavior was examined monthly in 1- to 3-month-old infants at elevated and low familial likelihood of ASD (n=60). At 2 years, infants were seen for a clinical best-estimate evaluation, resulting in 18 infants with ASD and 36 typically developing infants. Repeated-measures analysis of variance models were conducted to examine the effects of age, diagnostic group, and their interactions. Neurobehavioral maturation of infants diagnosed with ASD was largely comparable to typically developing infants from 1 to 3 months, with the exception of the development of attention. Object-focused attention was significantly attenuated for infants with ASD beginning at 2 to 3 months and was predictive of social-communication skills 2 years later. This is the first study to prospectively examine neonatal neurobehavior of infants at an elevated familial likelihood of ASD who later received a diagnosis. Despite relatively intact neurological and behavioral maturation in the neonatal period, attention to objects emerged as a key early indicator of ASD. This suggests a complex attentional vulnerability within the first 3 months of life that may be associated with cascading sequelae of social-communication challenges and the emergence of ASD.
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DOI：
10.1016/j.jaac.2019.12.012
发表时间：
2021-01
影响因子：
13.3
作者：
Macari, Suzanne;Milgramm, Anna;Reed, Jessa;Shic, Frederick;Powell, Kelly K.;Macris, Deanna;Chawarska, Katarzyna
通讯作者：
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DOI：
10.1111/j.1469-7610.2012.02538.x
发表时间：
2012-08
期刊：
Journal of child psychology and psychiatry, and allied disciplines
影响因子：
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作者：
Chawarska K;Macari S;Shic F
通讯作者：
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影响因子：
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作者：
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通讯作者：
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