Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers.
Association between daily cigarette consumption and hypertension moderated by CYP2A6 genotypes in Chinese male current smokers.
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DOI：
10.1038/jhh.2011.111
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发表时间：
2013-01
影响因子：
2.7
通讯作者：
中科院分区：
文献类型：
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作者：
本研究的目的是评估细胞色素P450酶2A 6（CYP 2A 6）基因型是否调节吸烟与高血压之间的关联。本研究采用结构式问卷对广州市某社区慢性病筛查项目的954名男性吸烟者进行了问卷调查。采集血液用于DNA提取和CYP 2A 6基因分型。根据2007年ESH-ESC实践指南定义高血压。在调整年龄、教育水平和其他潜在混杂因素后，采用多因素Logistic回归分析吸烟量和CYP 2A 6基因型与高血压的相互作用。多因素分析表明，与每天吸烟1-15支相比，每天吸烟15支以上者患高血压的风险显著增加（OR =1.59，95%可信区间CI =1.21-2.10），进一步提示吸烟与正常CYP 2A 6代谢基因型相互作用，增加患高血压的风险。吸烟量超过15支/日且CYP 2A 6代谢基因型正常者患高血压的危险性最高（OR=2.04，95%CI =1.11-3.75），而吸烟量1-15支/日且CYP 2A 6代谢基因型较慢者患高血压的危险性最高（OR = 2.04，95%CI =1.11-3.75）。这些结果表明吸烟量与高血压呈正相关，CYP 2A 6基因型可能会调节这种关系。
The purpose of this study was to assess whether cytochrome P450 enzyme 2A6 (CYP2A6) genotypes moderate the association between smoking and hypertension. In this study, 954 Chinese male current smokers from a community-based chronic disease screening project in Guangzhou were interviewed with a structured questionnaire about socio-demographic status, smoking and other health-related behaviors. Blood was collected for DNA extraction and CYP2A6 genotyping. Hypertension was defined according to 2007 ESH-ESC Practice Guidelines. A multivariate logistic regression was performed to examine the interaction between smoking quantity and CYP2A6 genotypes on hypertension after adjusting for age, education level and other potential confounders. Multivariate analyses indicated that smoking more than 15 cigarettes per day significantly increased the risk of hypertension (odds ratio (OR)=1.59, 95% confidence interval (CI)=1.21-2.10) compared with smoking 1-15 cigarettes per day, and further suggested that smoking interacted with normal CYP2A6 metabolizer genotype to increase the risk of hypertension. Smokers consuming more than 15 cigarettes per day with normal CYP2A6 metabolizer genotypes had the highest risk of hypertension (OR=2.04, 95% CI=1.11-3.75) compared with those consuming 1-15 cigarettes per day with slower CYP2A6 metabolizer genotypes. These findings demonstrated that smoking quantity was positively associated with hypertension and that CYP2A6 genotypes may moderate this relationship.
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DOI：
10.1111/j.1360-0443.2010.03353.x
发表时间：
2011-05
期刊：
Addiction (Abingdon, England)
影响因子：
--
作者：
Liu T;David SP;Tyndale RF;Wang H;Zhou Q;Ding P;He YH;Yu XQ;Chen W;Crump C;Wen XZ;Chen WQ
通讯作者：
Chen WQ
影响因子：
2.1
作者：
Nakajima, Miki;Yokoi, Tsuyoshi
通讯作者：
Yokoi, Tsuyoshi
影响因子：
1.9
作者：
Gu, DF;Hinks, LJ;Day, INM
通讯作者：
Day, INM
影响因子：
4.9
作者：
Au Bich Thuy;Blizzard, Leigh;Dwyer, Terence
通讯作者：
Dwyer, Terence
影响因子：
4.7
作者：
Fujieda, M;Yamazaki, H;Kamataki, T
通讯作者：
Kamataki, T